Efficiency of treatment with vitamin D on biochemical indexes, lipid profile, and fatty liver indexes in type 2 diabetic patients with vitamin D deficiency and nonalcoholic fatty liver

Mirhosseini, Mahmoud. and Asadi-Samani, Majid. and Dabbaghmanesh, Alireza. and Dayani, Mohammad Ali. and Sedehi, Morteza. (2016) Efficiency of treatment with vitamin D on biochemical indexes, lipid profile, and fatty liver indexes in type 2 diabetic patients with vitamin D deficiency and nonalcoholic fatty liver. Research Journal of Pharmaceutical, Biological and Chemical Sciences, 7 (6). pp. 1992-1997.

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Abstract

Prevalence of metabolic syndrome, type 2 diabetes, and non alcoholic fatty liver has been recently on rise in worldwide. This study was conducted to explore the association between vitamin D deficiency and incidence of fatty liver disease in type 2 diabetes patients and also to examine the efficacy of treatment with vitamin D in type 2 diabetes patients with vitamin D deficiency and non alcoholic fatty liver referring a specialty clinic in Shahrekord. In the first step (cross-sectional phase) of this two-step study, 108 patients with type 2 diabetes were examined for vitamin D level, biochemical indexes, lipid profile, and fatty liver indexes. In the second step (clinical trial phase), individuals with nonalcoholic fatty liver and vitamin D deficiency as treatment group underwent treatment with 50000 vitamin D units a week for 12 weeks. 3.96% of patients had fatty liver and 1.61% of patients had vitamin D deficiency of different severities. There was no significant association found between vitamin D deficiency and presence or severity of nonalcoholic fatty liver in patients (P > 0.05). Treatment with vitamin D had no significant effect on biochemical indices, liver function, fasting blood sugar, and hemoglobin A1c (P > 0.05), but serum level of cholesterol and low density lipoprotein (LDL) decreased in treatment patients compared to control group (P < 0.001). No significant association was found between vitamin D deficiency and presence or severity of nonalcoholic fatty liver; but treatment of type 2 diabetes patients with vitamin D supplementation decreased the serum level of cholesterol and LDL.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: Cholesterol, Fatty liver, Low density lipoprotein, Type 2 diabetes, Vitamin D
Subjects: WK Endocrine System
QU Biochemistry
Divisions: Reserach Vice-Chancellar Department > Cellular and Molecular Research Center
Reserach Vice-Chancellar Department > Clinical Biochemistry Research Center
Reserach Vice-Chancellar Department > Medical Plants Research Center
Reserach Vice-Chancellar Department > Social Determinants of Health Research Center
Reserach Vice-Chancellar Department > student research center
Depositing User: Users 1 not found.
Date Deposited: 02 Jul 2017 08:59
Last Modified: 04 Feb 2018 09:48
URI: http://eprints.skums.ac.ir/id/eprint/691

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