Association study of rs7192 polymorphism of HLA-DRA gene with male infertility occurrence in Isfahan province of Iran

Motovali-Bashi, Majid. and Akbari, Salehe. and Javadirad, Seyed morteza. (2018) Association study of rs7192 polymorphism of HLA-DRA gene with male infertility occurrence in Isfahan province of Iran. jskums., 20 (1).

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Abstract

Background and aims: One third of male factors related to infertilities are basically unknown and it has been predicted to be most of the unknown infertilities based on genetic abnormalities. On the other hands, the effect of HLA-DRA genes on spermatogenesis has been shown recently. So, this study was aimed to assess the association of rs7192 polymorphic site of HLA-DRA gene on male infertility in Isfahan province of Iran. Methods: 100 infertile men with azoospermia or severe oligozoospermia as case group and equal numbers of fertile men as control individuals were selected. Genomic DNA of peripheral blood was extracted after the written consent was taken. rs7192 polymorphic site has been analyzed by ARMS-PCR method in the case and control groups. Results: According to the results, the frequency of G allele was higher in infertile men than the T allele; but, allele frequency differences was not significant between the case and control groups (OR=0.86, P=0.47). However, it has been shown that GG homozygous in comparison to TT homozygous show an increased risk of male infertility but it was not statistically significant (OR=1.47, P=0.4). In parallel, comparison of GG + GT genotypes to TT ones was not also statistically significant between infertile and fertile men (OR=1.43, P=0.4). Conclusion: Association study of polymorphic rs7192 did not show any significant relationship among men infertile with azoospermia or severe oligozoospermia in Isfahan province of Iran.

Item Type: Article
Uncontrolled Keywords: Male infertility, HLA-DRA gene, rs7192 polymorphism
Subjects: QU Biochemistry > Cell biology and genetics
Divisions: Reserach Vice-Chancellar Department > Journal of Shahrekord University of Medical Sciences
Depositing User: zahra bagheri .
Date Deposited: 27 Jun 2018 06:37
Last Modified: 27 Jun 2018 06:37
URI: http://eprints.skums.ac.ir/id/eprint/6902

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