Use of non-genetic biomarkers including anti-GAD65, anti-Insulin (II) and C-peptide in differentiating MODY type diabetes in a population of diabetic patients in Isfahan province

Sarmadi, Akram. and Tabatabiefar, Mohammad Amin. and Tabatabaei, Fatemeh. and Gholizadeh, Azadeh. and Hashemzade Chaleshtori, Morteza. (2018) Use of non-genetic biomarkers including anti-GAD65, anti-Insulin (II) and C-peptide in differentiating MODY type diabetes in a population of diabetic patients in Isfahan province. jskums., 20 (2).

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Abstract

Background and aims: Diabetes mellitus is a group of metabolic disorders in the body, accompanied with increasing blood sugar levels. Diabetes is classified into 3 groups: Type 1 (T1DM), Type 2 (T2DM) and monogenic diabetes. Maturity-onset diabetes of the young (MODY) is a monogenic diabetes that is frequently mistaken for T1D or T2D. The aim of this study was to diagnose MODY using non-genetic biomarkers and determine its frequency in the population of Isfahan province. This, in addition to saving time and cost, is important for prognosis and appropriate treatment. Methods: In this analytical descriptive study 2085 diabetic patients with a 2-6 years of disease were examined and after assessing the clinical symptoms, in 57 cases with clinical symptoms for MODY, three markers (C-peptide, anti-GAD65 and anti-insulin (II)) were measured by ELISA method and compared with healthy cases and confirmed T1D and T2D patients. Results: In this analytical descriptive study, among 2085 diabetic patients, in 500 cases of them, the incidence of the disease was before the age of 25 years of old and after measuring 3 mentioned biochemical markers, 41 cases were negative for anti-GAD65 and anti-Insulin and had detectable C-peptide level and the differences in the levels of these three markers in suspected MODY group were meaningful (P<0.001 for anti-GAD65, P<0.017 for anti-Insulin (II) and P<0.009 for C-peptide). Conclusion: The use of proprietary non-genetic biomarkers is very valuable for MODY detection and could be used alongside other clinical features to screen a large number of patients with diabetes. Ultimately, only suspect cases must be selected for genetic tests.

Item Type: Article
Uncontrolled Keywords: MODY, Anti-GAD65, Anti Insulin (II), C-peptide.
Subjects: QU Biochemistry > Cell biology and genetics
Divisions: Reserach Vice-Chancellar Department > Journal of Shahrekord University of Medical Sciences
Reserach Vice-Chancellar Department > Cellular and Molecular Research Center
Depositing User: zahra bagheri .
Date Deposited: 27 Jun 2018 05:40
Last Modified: 27 Jun 2018 05:40
URI: http://eprints.skums.ac.ir/id/eprint/6896

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