Antifungal, antileishmanial, and cytotoxicity activities of various extracts of Berberis vulgaris (Berberidaceae) and its active principle berberine

Mahmoudvand, Hossein. and Ayatollahi Mousavi, Seyyed Amin. and Sepahvand, Asghar. and Sharififar, Fariba. and Ezatpour, Behrouz. and Gorohi, Fatemeh. and Saedi Dezaki, Ebrahim. and Jahanbakhsh, Sareh. (2014) Antifungal, antileishmanial, and cytotoxicity activities of various extracts of Berberis vulgaris (Berberidaceae) and its active principle berberine. ISRN pharmacology.

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Abstract

In this study, in vitro antidermatophytic activity against Trichophyton mentagrophytes, Trichophyton rubrum, Microsporum canis, and Microsporum gypseum was studied by disk diffusion test and assessment of minimum inhibitory concentration (MIC) using CLSI broth macrodilution method (M38-A2). Moreover, antileishmanial and cytotoxicity activity of B. vulgaris and berberine against promastigotes of Leishmania major and Leishmania tropica were evaluated by colorimetric MTT assay. The findings indicated that the various extracts of B. vulgaris particularly berberine showed high potential antidermatophytic against pathogenic dermatophytes tested with MIC values varying from 0.125 to >4 mg/mL. The results revealed that B. vulgaris extracts as well as berberine were effective in inhibiting L. major and L. tropica promastigotes growth in a dose-dependent manner with IC50 (50% inhibitory concentration) values varying from 2.1 to 26.6

Item Type: Article
Subjects: QV pharmacology > QV 752 Pharmacognosy
QX Parasitology
Divisions: Faculty of Medicine > Basic Sciences Academic Groups > Department of Parasitology and Mycology
Depositing User: zahra bagheri .
Date Deposited: 14 Jan 2018 08:56
Last Modified: 25 Feb 2018 06:43
URI: http://eprints.skums.ac.ir/id/eprint/6827

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