Effect of Kelussia odoratissima Mozaffarian (KOM) on hyperlipidemia: a clinical trial study

Rafieian-Kopaei, Mahmoud. and Shahrani, Mehrdad. and Pilehvarian, Ali Asghar. and Kheyri, Soleiman. and Rabiei, Rahmatollah and Momeni, Ali. and Asgari, Azam. and Parvin, Neda. (2009) Effect of Kelussia odoratissima Mozaffarian (KOM) on hyperlipidemia: a clinical trial study. SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES JOURNAL, 10 (41).

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Abstract

Background and aim: Flavonoids constitute a large group of polyphenolic compounds and have been shown to reduce risk of various heart diseases. KOM is a plant which contains flavonoids. Therefore, in this study, we aimed to figure out the anti-hyperlipidemic effect of KOM in patients, on lovastatin treatment. Methods: In this clinical trial study, 74 patients referred to internal clinic of Hajar hospital in Shahrekord, Iran, were divided randomly into two groups. Control group was given lovostatin (40 mg/day) and case group was given lovostatin (40 mg/day) and 2gr KOM powder. The levels of serum lipids (including triglyceride, total cholesterol, LDL, HDL) and FBS were determined in both groups at the beginning, 2 weeks and one month after starting day of the experiment. Statistical analysis was performed by ANOVA. Results: A significant reduction was observed in cholesterol, TG, LDL and VLDL levels of patients (P<0.001). However, this reduction was not significant in two groups (P>0.05). The HDL level was increased following KOM usage (P<0.05), but it was reduced in control group (P<0.05). LDL/HDL was reduced in both groups (P<0.001). The level of FBS was not significantly changed during the study. Conclusion: Consumption of KOM may have beneficial effect on hyperlipidemic patients by enhancing serum levels of HDL.

Item Type: Article
Uncontrolled Keywords: TRIGLYCERIDE, CHOLESTEROL, HYPERLIPIDEMIA, KELUSSIA ODORATISSIMA MOZAFFARIAN
Subjects: WG Cardiovascular System
QV pharmacology
QV pharmacology > QV 752 Pharmacognosy
Divisions: Faculty of Medicine > Basic Sciences Academic Groups > Department of Physiology
Faculty of Medicine > Department of Clinical Sciences > Department of Internal Medicine
Faculty of Medicine > Department of Clinical Sciences > Department of pharmacology
Depositing User: zahra bagheri .
Date Deposited: 14 Jan 2018 05:14
Last Modified: 15 Apr 2018 06:04
URI: http://eprints.skums.ac.ir/id/eprint/6816

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