Bupropion induces sniffing: a possible dopaminergic mechanism

Zarrindast, MohammadReza. and Hojjati, Mohammad reza. and Pejhan, Akbar. and Soleimannejad, Elaheh. (1996) Bupropion induces sniffing: a possible dopaminergic mechanism. European neuropsychopharmacology, 6 (4).

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The effect of bupropion, an antidepressant drug, on sniffing behaviour was examined in rats. Animals treated intraperitoneally (i.p.) with different doses of bupropion (5-40 mg/kg) showed sniffing behaviour in a dose-related manner. Pretreatment of animals (i.p.) with the dopamine antagonists SCH 23390 (0.025-0.1 mg/kg) or sulpiride (12.5-50 mg/kg) decreased the sniffing induced by bupropion. Reserpine pretreatment (2.5 mg/kg, i.p., 18 h) alone and in combination with o~-methyl-p-tyrosine (AMPT; 250 mg/kg, i.p.) also reduced the behaviour produced by the drug. The et-adrenoceptor phenoxybenzamine (5 and 10 mg/kg, i.p.) and the [3-adrenoceptor antagonist propranolol (5 and 10 mg/kg, i.p.) administered 60 rain prior to bupropion did not affect the drug's effect on sniffing. Propranolol alone, however, induced sniffing. The antimuscarinic atropine (5 and 10 mg/kg, i.p.) administered 30 min prior to bupropion increased the bupropion response. Atropine alone induced vigorous sniffing. It is concluded that bupropion induced sniffing through a dopaminergic mechanism

Item Type: Article
Uncontrolled Keywords: Bupropion; Dopamine antagonists; Reserpine; a-Methyl-p-tyrosine; Sniffing; Rats
Subjects: QT physiology
QV pharmacology
Divisions: Faculty of Medicine > Basic Sciences Academic Groups > Department of Physiology
Depositing User: Users 1 not found.
Date Deposited: 02 Jan 2018 08:06
Last Modified: 05 Feb 2018 08:03
URI: http://eprints.skums.ac.ir/id/eprint/6787

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