Spatial navigation impairment in mice lacking cerebellar LTD: a motor adaptation deficit?

Burguiere, Eric. and Arleo, Angelo. and Hojjati, Mohammad reza. and Elgersma, Ype. and Zeeuw, Chris I. De. and Berthoz, Alain. and Rondi-Reig, Laure. (2005) Spatial navigation impairment in mice lacking cerebellar LTD: a motor adaptation deficit? Nature neuroscience, 8 (10).

[img] Text
10.pdf

Download (1MB)

Abstract

L7-PKCI transgenic mice, having a specific lack of parallel fiber-Purkinje cell LTD, were tested with two different mazes to dissociate the relative importance of declarative and procedural components of spatial navigation. Our data bring evidence for a deficit of L7-PKCI mice in the acquisition of an adapted goal-oriented behavior, i.e. in the procedural component of the task. This finding supports the hypothesis that cerebellar LTD may subserve a general sensory-motor adaptation process shared by motor and spatial learning functions.

Item Type: Article
Subjects: QT physiology
WL Nervous system
QU Biochemistry
Divisions: Faculty of Medicine > Basic Sciences Academic Groups > Department of Physiology
Depositing User: zahra bagheri .
Date Deposited: 02 Jan 2018 07:49
Last Modified: 05 Feb 2018 08:57
URI: http://eprints.skums.ac.ir/id/eprint/6786

Actions (login required)

View Item View Item