Anxiety- and Depressive-Like Behaviors are Associated with Altered Hippocampal Energy and Inflammatory Status in a Mouse Model of Crohn’s Disease

Haj-Mirzaian, Arya. and Amiri, Shayan. and Amini-Khoei, Hossein. and Hosseini, Mir-Jamal. and Haj-Mirzaian, Arvin. and Momeny, Majid. and Rahimi-Balaei, Maryam. and Dehpour, Ahmad Reza. (2017) Anxiety- and Depressive-Like Behaviors are Associated with Altered Hippocampal Energy and Inflammatory Status in a Mouse Model of Crohn’s Disease. Neuroscience, 366.

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Abstract

Abstract—Depression and anxiety are common comorbid disorders observed in patients with inflammatory bowel disease (IBD). Increasing line of evidence indicates that immune-inflammatory responses are involved in cooccurrence of mood disorders and IBD. However, the mechanisms through which immune-inflammatory pathways modulate this comorbidity are not yet understood. This study investigated the role of innate immunity in the development of behavioral abnormalities associated with an animal model of Crohn’s disease (CD). To do this, we induced colitis in male adult mice by intrarectal (i.r.) injection of DNBS (Dinitrobenzene sulfonic acid). After 3 days, we performed behavioral tests for anxiety- and depressive-like behaviors as well as tissue collection. Our results showed that DNBS-induced colonic inflammatory responses were accompanied by infiltration of inflammatory cells, and increased expression of genes involved in toll-like receptor signaling pathway in intestinal tissue. Furthermore, the DNBS-treated mice showed depressive- and anxiety-like behaviors which were associated with increased expression of the inflammatory genes and abnormal mitochondrial function in the hippocampus. These results suggest that peripheral inflammation is able to increase the transcriptional level of the genes in tolllike receptor pathway, induces abnormal mitochondrial function in the hippocampus, and these negative effects may be involved in the co-occurrence of anxiety and depression in early stages of CD. � 2017 IBRO. Published by Elsevier Ltd. All rights reserved.

Item Type: Article
Uncontrolled Keywords: depression, anxiety, Crohn’s disease, oxidative stress, hippocampus, toll-like receptor pathway.
Subjects: WI Digestive System
WM Psychiatry
QU Biochemistry > Cell biology and genetics
Divisions: Reserach Vice-Chancellar Department > Cellular and Molecular Research Center
Depositing User: Users 1 not found.
Date Deposited: 31 Dec 2017 06:24
Last Modified: 18 Feb 2018 09:22
URI: http://eprints.skums.ac.ir/id/eprint/6761

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