Lithium attenuates the proconvulsant effect of adolescent social isolation stress via involvement of the nitrergic system

Amiri, Shayan. and Haj-Mirzaian, Arya. and Amini-Khoei, Hossein. and Shirzadian, Armin. and Rahimi-Balaei, Maryam. and Razmi, Ali. and Bergen, Hugo. and Rastegar, Mojgan. and Kordjazy, Nastaran. and Haj-Mirzaian, Arvin. and Ejtemai-Mehr, Shahram. and Dehpour, Ahmad Reza. (2016) Lithium attenuates the proconvulsant effect of adolescent social isolation stress via involvement of the nitrergic system. Epilepsy & Behavior, 61.

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Abstract

In this study, we tested whether acute administration of lithium mitigates the deleterious effect of adolescent social isolation stress (SIS) on seizure susceptibility. In comparison with socially conditioned (SC) mice, isolated conditioned (IC) mice exhibited an increase in seizure susceptibility to pentylenetetrazole. Acute administration of lithium (10 mg/kg) reversed the proconvulsant effect of SIS in IC mice, but this effect was not observed in SC mice. Coadministration of subthreshold doses of lithium (3 mg/kg) with nitric oxide synthase (NOS) inhibitors reversed the effect of SIS on seizure susceptibility and decreased hippocampal nitrite levels in IC animals. In addition, a subthreshold dose of a nitric oxide precursor reduced the protective effect of lithium on seizure susceptibility and increased nitrite levels in the hippocampus of IC mice. These results suggest that lithium exerts a protective influence against the proconvulsant effect of adolescent SIS via a nitrergic system that includes activation of neuronal NOS in the hippocampus.

Item Type: Article
Uncontrolled Keywords: Social isolation stress,Adolescence,Lithium,Nitrergic system Seizure
Subjects: WL Nervous system
QU Biochemistry
Divisions: Reserach Vice-Chancellar Department > Cellular and Molecular Research Center
Depositing User: zahra bagheri .
Date Deposited: 31 Dec 2017 05:50
Last Modified: 18 Feb 2018 09:41
URI: http://eprints.skums.ac.ir/id/eprint/6758

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