Morphine modulates the effects of histamine H1 and H3 receptors on seizure susceptibility in pentylenetetrazole-induced seizure model of mice

Amini-Khoei, Hossein. and Rahimi-Balaei, Maryam. and Amiri, Shayan. and Haj-Mirzaian, Arya. and Hassanipour, Mahsa. and Shirzadian, Armin. and Gooshe, Maziar. and Alijanpour, Sakineh. and Ejtemaie Mehr, Shahram. and Dehpour, Ahmad Reza. (2015) Morphine modulates the effects of histamine H1 and H3 receptors on seizure susceptibility in pentylenetetrazole-induced seizure model of mice. European journal of pharmacology, 769.

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Abstract

Histamine regulates release of neurotransmitters such as dopamine, serotonin, gamma-aminobutyric acid (GABA), glutamate and also is involved in several functions in central nervous system (CNS). It has been shown that histamine participates in disorders like seizure. It has been well documented that morphine dose-dependently induces anti or proconvulsant effects. In the current study, we firstly showed that morphine (1 mg/kg) exerts anticonvulsant effects which significantly reversed by naltrexone administration. Secondly, we determined seizure threshold for H1 and H3 receptors agonists and antagonists in mouse model of pentylenetetrazole (PTZ)-induced clonic seizures. Our results showed that activation of H1 receptors by 2-(2-Pyridyl)-ethylamine exerts anticonvulsant properties while inhibition of H1 receptors by pyrilamine maleate induced proconvulsant effects. Furthermore, we showed that immepip dihydrobromide, a H3 receptor agonist, increased seizure susceptibility to PTZ whereas thioperamide, a H3 receptor antagonist increased seizure threshold. We also revealed that pretreatment with morphine potently reversed the effects of histaminergic system on seizure threshold suggesting the involvement of opioid system in alteration of seizure threshold by histaminergic drugs

Item Type: Article
Uncontrolled Keywords: Seizure,Histamine,Morphine,PT
Subjects: WL Nervous system
QV pharmacology
Divisions: Reserach Vice-Chancellar Department > Cellular and Molecular Research Center
Depositing User: zahra bagheri .
Date Deposited: 31 Dec 2017 04:38
Last Modified: 18 Feb 2018 09:30
URI: http://eprints.skums.ac.ir/id/eprint/6754

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