Experiencing neonatal maternal separation increased the seizure threshold in adult male mice: Involvement of the opioid system

Amini-Khoei, Hossein. and Amiri, Shayan. and Shirzadian, Armin. and Haj-Mirzaian, Arya. and Alijanpour, Sakineh. and Rahimi-Balaei, Maryam. and Mohammadi-Asl, Ali. and Hassanipour, Mahsa. and Ejtemaie Mehr, Shahram. and Dehpour, Ahmad Reza. (2015) Experiencing neonatal maternal separation increased the seizure threshold in adult male mice: Involvement of the opioid system. Epilepsy & Behavior, 52.

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Abstract

Experiencing early-life stress has been considered as a potent risk factor for the development of many of brain disorders, including seizures. Intervening mechanisms through which neonatal maternal separation (MS) alters the seizure susceptibility in adulthood have not been well studied. In the current study, by applying 180 min of MS stress (PND 2–14), we determined the seizure susceptibility and considered the role of the opioid system. Maternal separation increased the seizure threshold, and administration of anticonvulsant/proconvulsant doses of morphine (1 and 30 mg/kg, respectively) reversed the impact of MS. Using tail flick and hot plate tests, we exposed animals to 30 min Restraint stress (RS) and found that MS decreased the pain threshold, suggesting the hyporesponsiveness of the opioid system. These results supported the abnormal seizure activity observed in the MS mice and suggested that abnormalities in the opioid system following MS alter seizure susceptibility in later life.

Item Type: Article
Uncontrolled Keywords: Maternal separation; Opioid system; PTZ; Seizure susceptibility; Stress
Subjects: WL Nervous system
QV pharmacology
Divisions: Reserach Vice-Chancellar Department > Medical Plants Research Center
Depositing User: Users 1 not found.
Date Deposited: 30 Dec 2017 08:28
Last Modified: 18 Feb 2018 09:32
URI: http://eprints.skums.ac.ir/id/eprint/6752

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