Occult Hepatitis B Infection in Patients With Cryptogenic Liver Cirrhosis in Southwest of Iran

Hashemi, Seyed Jalal. and Hajiani, Eskandar. and Masjedizadeh, Abdolrahim. and Makvandi, Manoochehr. and Shayesteh, Ali Akbar. and Alavinejad, Seyed Pejman. and Kadkhodaei, Ahmad. and Shahbazian, Heshmatollah. and Jasemi, Farzad. and Karimi, Mohamad. (2015) Occult Hepatitis B Infection in Patients With Cryptogenic Liver Cirrhosis in Southwest of Iran. Jundishapur journal of microbiology, 8 (3).


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Background: Chronic hepatitis B virus (HBV) infection has a broad spectrum of manifestation, ranging from silent carrier state to advanced cirrhosis and hepatocellular carcinoma. The persistence of HBV DNA in serum and hepatocytes of the cirrhotic patient could be detected by molecular techniques in spite of negative HBV serologic markers. Objectives: This case-control study was designed to evaluate the prevalence of occult HBV infection (OBI) in patients with cryptogenic liver cirrhosis in comparison with healthy subjects. Patients and Methods: Of 165 patients with liver cirrhosis, 50 consecutive patients with cryptogenic cirrhosis and 80 healthy individual without any risk factors as a control group were enrolled in this study. Their sera were tested for HBV DNA using nested PCR method. Results: Of 50 patients with cryptogenic cirrhotic, 36 (72%) were male. The mean age of patients was 53.34 ± 14.73 years; 80 healthy subjects were selected as control group with mean age of 32.65 ± 8.51 years; 7 (14%) of the patients with cryptogenic cirrhosis showed positive HBV DNA by PCR, while HBV DNA was negative for the control group (P = 0.0001); 4 (57%) cases with positive HBV shown by PCR were negative for anti-HBc and anti-HBs tests. The mean level of transaminases was significantly higher in patients with cirrhosis. There were no significant differences in demographic parameters, transaminases level and degree of hepatic failure among cirrhotic patients with and without OBI. Conclusions: The prevalence of OBI was relatively high in patients with cryptogenic cirrhosis. OBI was found among the patients above 40 years old. Prospective cohort studies are needed to evaluate the clinical significance of OBI.

Item Type: Article
Uncontrolled Keywords: Liver Cirrhosis; Infection; Hepatitis B
Subjects: WC Communicable Diseases > Infection.Bacterial Infections
WI Digestive System
Divisions: Faculty of Medicine
Depositing User: Users 1 not found.
Date Deposited: 26 Dec 2017 06:47
Last Modified: 18 Feb 2018 07:42
URI: http://eprints.skums.ac.ir/id/eprint/6724

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