Anti-platelet aggregation assay and chemical composition of essential oil from Allium atroviolaceum Boiss growing in Iran.

Lorigooini, Zahra. and Kobarfard, Farzad. and Ayatollahi, Seyed Abdolmajid. (2014) Anti-platelet aggregation assay and chemical composition of essential oil from Allium atroviolaceum Boiss growing in Iran. International Journal of Biosciences (IJB), 5 (2).

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Abstract

Plants belonging to genera Allium have widely been acquired as food and medicine. Their wide use was mainly due to the medicinal properties attributed to these plants over the centuries, lately supported by epidemiological and research studies. In this study, essential oil constituents of Allium atroviolaceum growing in Shahr-e-kord, Iran, were investigated through gas chromatography/mass spectrometry (GC-MS) technique. In this essential oil two major constituents were trisulfide, di-2-propenyl (26.85%) and diallyl disulphide (10.98%) while trans-2-(2- pentenyl) furan (0.02%) and Limonene (0.06%) have been identified in lower amounts. The in-vitro antiplatelet activity of essential oil was evaluated, using arachidonic acid (AA) and adenosine diphosphate (ADP) as the platelet aggregation inducers. The results showed that essential oil of Allium atroviolaceum with IC50; 0.25 mg/ml and 0.47 mg/ml inhibited in-vitro platelet aggregation induced by AA and ADP respectively.

Item Type: Article
Uncontrolled Keywords: Allium atroviolaceum, essential oil, GC-MS, antiplatelet aggregation, steam distillation.
Subjects: QV pharmacology > QV 752 Pharmacognosy
Divisions: Faculty of Medicine > Department of Clinical Sciences > Department of pharmacology
Depositing User: zahra bagheri .
Date Deposited: 20 Dec 2017 06:30
Last Modified: 25 Feb 2018 06:49
URI: http://eprints.skums.ac.ir/id/eprint/6666

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