POTENTIATING EFFECTS OF MORPHINE ANALGESIA WITH CARBAMAZEPINE ON THE POSTOPERATIVE PAIN IN MORPHINE- DEPENDENT RATS

Naseri, Kobra. and Sabetkasaei, Masoumeh. and Saghaei, Elham. and Moini Zanjani, Taraneh. (2009) POTENTIATING EFFECTS OF MORPHINE ANALGESIA WITH CARBAMAZEPINE ON THE POSTOPERATIVE PAIN IN MORPHINE- DEPENDENT RATS. IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY, 19.

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Abstract

Postoperative pain and its control remains one of the most important issues in the field of surgery and health care system. Morphine is a potent and effective analgesic. But substance abuse patients can manifest cross tolerance to drugs, making it difficult to predict their analgesic or anesthetic requirements. The anticonvulsant drug, carbamazepine (cbz), has many pharmacological effects. In this study we evaluated the effect of various doses of carbamazepine injected Intraperitoneally (i.p.) on postoperative pain in morphine-dependent and naïve rats. Rats were addicted by i.p. morphine. After anesthesia a 1-cm longitudinal incision was made through the skin, fascia and muscle of the plantar aspect of the hind paw and then sutured. Both morphine-dependent and naïve rats received carbamazepine or/and morphine i.p. 2h and 24h after surgery. Paw Withdrawal Threshold by Von Frey Filament obtained every 0.5h after drug injection up to 3h (at surgical day and next day). We saw that the combination of carbamazepine 5mg/kg+morphine 3mg/kg produced more analgesic effects in morphinedependent rats compared to cbz or morphine alone and this combination had same effect of morphine 3mg/kg alone in naïve rats (P<0.05). carbamazepine may potentiate the analgesic effect of chronically administration of morphine.

Item Type: Article
Uncontrolled Keywords: CARBAMAZEPINE, POSTOPERATIVE PAIN, MORPHINE DEPENDENT RATS, MECHANICAL ALLODYNIA
Subjects: WO Surgery
QV pharmacology
Divisions: Faculty of Medicine > Department of Clinical Sciences > Department of pharmacology
Depositing User: Users 1 not found.
Date Deposited: 19 Dec 2017 11:08
Last Modified: 20 May 2018 05:18
URI: http://eprints.skums.ac.ir/id/eprint/6663

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