Review on herbal medicine on brain ischemia and reperfusion

Jivad, Nahid. and Rabiei, Zahra. (2015) Review on herbal medicine on brain ischemia and reperfusion. Asian Pacific Journal of Tropical Biomedicine, 5 (10).


Download (314kB) | Preview


Brain ischemia and reperfusion is the leading cause of serious and long-range disability in the world. Clinically significant changes in central nervous system function are observed following brain ischemia and reperfusion. Stroke patients exhibit behavioral, cognitive, emotional, affective and electrophysiological changes during recovery phase. Brain injury by transient complete global brain ischemia or by transient incomplete brain ischemia afflicts a very large number of patients in the world with death or permanent disability. In order to reduce this damage, we must sufficiently understand the mechanisms involved in brain ischemia and reperfusion and repair to design clinically effective therapy. Cerebral ischemia and reperfusion is known to induce the generation of reactive oxygen species that can lead to oxidative damage of proteins, membrane lipids and nucleic acids. A decrease in tissue antioxidant capacity, an increase in lipid peroxidation as well as an increase in lipid peroxidation inhibitors have been demonstrated in several models of brain ischemia. This paper reviews the number of commonly used types of herbal medicines effective for the treatment of stroke. The aim of this paper was to review evidences from controlled studies in order to discuss whether herbal medicine can be helpful in the treatment of brain ischemia and reperfusion.

Item Type: Article
Uncontrolled Keywords: Brain ischemia,Reperfusion,Medicinal plants,Reactive oxygen species,Blood–brain barrier
Subjects: WL Nervous system
QV pharmacology > QV 752 Pharmacognosy
Divisions: Faculty of Medicine > Department of Clinical Sciences > Department of Neurological Diseases
Reserach Vice-Chancellar Department > Medical Plants Research Center
Depositing User: Users 1 not found.
Date Deposited: 18 Dec 2017 07:47
Last Modified: 06 Mar 2018 07:32

Actions (login required)

View Item View Item