Biased Treg/Th17 balance away from regulatory toward inflammatory phenotype in relapsed multiple sclerosis and its correlation with severity of symptoms

Jamshidian, Azam. and Shaygannejad, Vahid. and Pourazar, Abbasali. and Zarkesh Esfahani, Hamid. and Gharagozloo, Marjan. (2013) Biased Treg/Th17 balance away from regulatory toward inflammatory phenotype in relapsed multiple sclerosis and its correlation with severity of symptoms. Journal of Neuroimmunology, 262 (1).

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Abstract

The opposing immune functions of Treg and Th17 lymphocytes and the plasticity of Treg/Th17 differentiation, has led us to investigate the effects of their fluctuations and counterbalance in autoimmune condition of multiple sclerosis (MS). Evaluation of Treg and Th17 frequency in peripheral blood of a group of relapsed MS patients, showed a decrease in Treg/Th17 ratio compared to that of healthy controls. A reverse correlation between these subsets was observed in controls but not in patient groups. Both Treg frequency and Treg/Th17 ratio were negatively correlated with severity of symptoms. There was shown to be an enduring increase in Treg frequency associated with MS disease.

Item Type: Article
Uncontrolled Keywords: Th17,Treg,Multiple sclerosis
Subjects: WL Nervous system
QW Microbiology and Immunology
Divisions: Faculty of Medicine > Basic Sciences Academic Groups > Department of Immunology
Depositing User: zahra bagheri .
Date Deposited: 10 Dec 2017 09:02
Last Modified: 05 Feb 2018 07:21
URI: http://eprints.skums.ac.ir/id/eprint/6529

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