Effects of Matricaria chamomilla extract on motor coordination impairment induced by scopolamine in rats

Asgharzadeh, Samira. and Rabiei, Zahra. and Rafieian-Kopaei, Mahmoud. (2015) Effects of Matricaria chamomilla extract on motor coordination impairment induced by scopolamine in rats. Asian Pacific Journal of Tropical Biomedicine, 5 (10).

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Abstract

Abstract Objective To evaluate the effect of ethanolic extract of chamomile on balance and motor learning in rats receiving scopolamine and intact rats. Methods Fourty-two rats were divided into 6 groups (n = 7). Control group received distilled water. Rats in Group 2 were given 1 mg/kg scopolamine. Groups 3 and 4 received chamomile extract 200 mg/kg and 500 mg/kg, respectively, and scopolamine simultaneously for 20 days. Intact groups (Groups 5 and 6) only received chamomile extract 200 mg/kg and 500 mg/kg, respectively. Motor coordination of rats was assessed with rotarod apparatus. Results According to the obtained results, compared with the control group, scopolamine significantly decreased time spent on rotarod performance (P < 0.001). Compared with scopolamine group, the strength and staying on rotarod apparatus in Group 3 significantly increased (P < 0.05). The results of this research showed that intact groups that received only chamomile extract at doses of 200 mg/kg and 500 mg/kg significantly increased time spent on rotarod, compared with scopolamine group (P < 0.001). Conclusions The results of this study indicated the high antioxidant property and protective effect of chamomile extract on motor coordination in the groups that received scopolamine.

Item Type: Article
Uncontrolled Keywords: Motor coordination impairment Chamomile plant Scopolamine Rat
Subjects: QV pharmacology > QV 752 Pharmacognosy
Divisions: Reserach Vice-Chancellar Department > Medical Plants Research Center
Depositing User: Users 1 not found.
Date Deposited: 10 Dec 2017 07:30
Last Modified: 24 Jul 2018 05:11
URI: http://eprints.skums.ac.ir/id/eprint/6522

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