Neuroprotective Effect of Coenzyme Q10 in Hippocampal Injury in Balb/c Mouse

Rigi, Sara. and Sakhaei, Abolhassan. and Niknam Asl, Azadeh. and Alizadeh, Akram. and Beigi, Fatemeh. and Mehdizadeh, Mehdi. and Ketabi, Majid. and Soleimani, Mansooreh. (2014) Neuroprotective Effect of Coenzyme Q10 in Hippocampal Injury in Balb/c Mouse. Journal of Applied Biotechnology Reports, 1 (2).


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Coenzyme Q10 is a promising agent for neuroprotection in neurodegenerative diseases. Neuroprotective effects of Coenzyme Q10 demonstrated in some neurodegenerative diseases such as Parkinson, Alzheimer and etc. Hippocampus is home of these diseases. We assayed Coenzyme Q10 effects on Hippocampal injury model and our hypothesis is that Coenzyme Q10 has Neuroprotective effects in some neurodegenerative diseases via hippocampus. For this purpose 24 Balb/c mouse took in 4 groups: Control (Without any treatment), Vehicle (Treated with sesame oil as Coenzyme Q10 vehicle), Hyppocampal injury model (Treated with Trimethyltin chlorideneurotoxin, 2.5 mg per kg IP), and test (Treated with Coenzyme Q10 after Trimethyltin chloride injection, 10 mg per kg IP for 2 weeks). After two weeks brain harvested and hippocampus tissue assayed by Nissl and Tunnel staining. Hystological study showed significantly increase of normal cells and decrease of apoptotic cells in test group after Coenzyme Q10 treatment in hippocampus. This study showed Coenzyme Q10 has protective effects in hippocampus after injury and it seems that Neuroprotective effects of Coenzyme Q10 in some neurodegenerative diseases com from that.

Item Type: Article
Uncontrolled Keywords: Coenzyme Q10, Neuroprotection, Trimethyltin Chloride
Subjects: WL Nervous system
WM Psychiatry
QV pharmacology > QV 752 Pharmacognosy
Divisions: Reserach Vice-Chancellar Department > Cellular and Molecular Research Center
Depositing User: Users 1 not found.
Date Deposited: 29 Nov 2017 05:12
Last Modified: 28 May 2018 05:58

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