The effect of intrathecal delivery of bone marrow stromal cells on hippocampal neurons in rat model of Alzheimer's disease.

Eftekharzadeh, Mina. and Nobakht, Maliheh. and Alizadeh, Akram. and Soleimani, Mansooreh. and Hajghasem, Mahmood. and Kordestani Shargh, Bahareh. and Karkuki Osguei, Nushin. and Behnam, Babak. and Samadi kuchaksaraei, Ali. (2015) The effect of intrathecal delivery of bone marrow stromal cells on hippocampal neurons in rat model of Alzheimer's disease. Iranian journal of basic medical sciences, 18 (5).

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Abstract

OBJECTIVES: Intracerebral injection of bone marrow stromal cells (BMSCs) is being investigated as a therapeutic tool to prevent Alzheimer's disease (AD). Our aim was to investigate the effects of BMSCs by intrathecal injection in AD rat model. MATERIALS AND METHODS: BMSCs were obtained from the bone marrow of Wistar rat and transplanted into AD rat model via intrathecal injection. The rat model had received an injection of β amyloid into the hippocampus for histological and immunohistochemical studies. RESULTS: Histological examination of the brains in transplanted rats compared to controls demonstrated the migration of BrdU-labeled BMSCs from the site of delivery, confirmed the differentiation of BMSCs transplanted cells into the cholinergic neurons, and increased number of healthy and decreased number of dark neurons. CONCLUSION: Our results showed that BMSCs intratechal administration could be a promising method for treatment of Alzheimer's disease in rat model.

Item Type: Article
Uncontrolled Keywords: Alzheimer’s disease Bone marrow stromal cells Intrathecal delivery Rat model
Subjects: WM Psychiatry
QU Biochemistry > Cell biology and genetics
Divisions: Reserach Vice-Chancellar Department > Cellular and Molecular Research Center
Depositing User: Users 1 not found.
Date Deposited: 28 Nov 2017 08:19
Last Modified: 20 May 2018 10:17
URI: http://eprints.skums.ac.ir/id/eprint/6455

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