Induction of spontaneous neo-angiogenesis and tube formation in human endometrial stem cells by bioglass

Shamosi, Atefeh. and Farokhi, Mehdi. and Ai, Jafar. and Sharifi, Esmaeel. (2015) Induction of spontaneous neo-angiogenesis and tube formation in human endometrial stem cells by bioglass. Journal of Medical Hypotheses and Ideas, 9 (2).


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Abstract Endothelial dysfunction is a broad pathological disorder of the endothelium (innermost layer of blood vessels) which is assigned by vasoconstriction, thrombosis and ischemic diseases, alone or with other disorders such as coronary artery disease, hypertension and atherosclerosis. The fundamental imperfection of endothelial layer injury due to decrease in the number of functional endothelial progenitor cells and inhibition of endothelial progenitor cell differentiation, resulting into impairment of angiogenesis, vasculogenesis, tube formation properties and endothelial regeneration. Multiple significant therapeutic achievements in impediment and treatment of vascular diseases include the use of antithrombotic agents, statin class of drugs, lifestyle changes, and revascularization therapies. Nevertheless, a certain number of patients with endothelial dysfunction disease are resistant to the usual therapies, so new therapeutic strategies for endothelial dysfunction disease are urgently needed. Recent studies show that stem cell-based therapy has important promise for repair and treatment of vascular dysfunction. In this study, we describe a novel choice for treatment of endothelial dysfunction in vascular regenerative medicine via the human endometrial stem cell culture (as a new source for the increasing the number of endothelial progenitor cells) with bioglass (angiogenic agent) to investigate the enhancing expression of CD34, CD31 and gene markers of endothelial progenitor cells and endothelial cells. In the end, application of immunoprivileged, readily available sources of adult stem cells like human endometrial stem cells with bioglass would be a promising strategy to increase the number of endothelial progenitor cells and promote spontaneous angiogenesis needed in endothelial layer repair and regeneration. �2015 Tehran University of Medical Sciences. Published by Elsevier Ltd. This is an open access article

Item Type: Article
Uncontrolled Keywords: Endothelial dysfunction;Angiogenesis;Vasculogenesis;Human endometrial stem,cells;Endothelial progenitor cells;Bioglass
Subjects: WG Cardiovascular System
QU Biochemistry > Cell biology and genetics
Divisions: Reserach Vice-Chancellar Department > Cellular and Molecular Research Center
Depositing User: Users 1 not found.
Date Deposited: 22 Nov 2017 09:32
Last Modified: 18 Feb 2018 04:34

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