Preparation of a biomimetic composite scaffold from gelatin/collagen and bioactive glass fibers for bone tissue engineering.

Sharifi, Esmaeel. and Azami, Mahmoud. and Kajbafzadeh, Abdol-Mohammad. and Moztarzadeh, Fatollah. and Faridi-Majidi, Reza. and Shamousi, Atefeh. and Karimi, Roya. and Ai, Jafar. (2016) Preparation of a biomimetic composite scaffold from gelatin/collagen and bioactive glass fibers for bone tissue engineering. Materials Science and Engineering: C, 59.

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Abstract

Bone tissue is a composite material made of organic and inorganic components. Bone tissue engineering requires scaffolds that mimic bone nature in chemical and mechanical properties. This study proposes a novel method for preparing composite scaffolds that uses sub-micron bioglass fibers as the organic phase and gelatin/collagen as the inorganic phase. The scaffolds were constructed by using freeze drying and electro spinning methods and their mechanical properties were enhanced by using genipin crosslinking agent. Electron microscopy micrographs showed that the structure of composite scaffolds were porous with pore diameters of approximately 70-200μm, this was again confirmed by mercury porosimetery. These pores are suitable for osteoblast growth. The diameters of the fibers were approximately 150-450nm. Structural analysis confirmed the formation of desirable phases of sub-micron bioglass fibers. Cellular biocompatibility tests illustrated that scaffolds containing copper ion in the bioglass structure had more cell growth and osteoblast attachment in comparison to copper-free scaffolds.

Item Type: Article
Uncontrolled Keywords: Bioglass fibers; Biomimetic; Bone tissue engineering; Composite; Copper
Subjects: WG Cardiovascular System
QT physiology > physics.mathematics.engineering
QU Biochemistry > Cell biology and genetics
Divisions: Reserach Vice-Chancellar Department > Cellular and Molecular Research Center
Depositing User: Users 1 not found.
Date Deposited: 22 Nov 2017 08:46
Last Modified: 13 Feb 2018 10:51
URI: http://eprints.skums.ac.ir/id/eprint/6402

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