Mutation detection in exons 3, 10, 12 of BRCA1 gene in 30 patients affected with familial breast cancer

Teimori, Hossein. and Mehdipour, Parvin. and Atri, Morteza. and Mirzai, MohammadReza. (2001) Mutation detection in exons 3, 10, 12 of BRCA1 gene in 30 patients affected with familial breast cancer. Journal of Gorgan University of Medical Sciences, 3 (2).

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Abstract

Breast Cancer is one of the most common causes of death due to Cancer in women. More than half of hereditary breast/ovarian Cancer families could be attributed to mutation in breast Cancer susceptibility gene BRCA1. This study was performed on blood samples of 30 women who affected with familial breast Cancer. Non-radioactive PCR-SSCP technique was utilized mutation screening in exons 3, 10, 12 of BRCA1 gene. Two shifts in exon 3 and also two in exon 12 was detected, but no shift in exon 10 was found. Due to low number of …

Item Type: Article
Subjects: WO Surgery
WQ Obstetrics
Divisions: Faculty of Medicine > Department of Clinical Sciences > Department of Anesthesiology
Depositing User: Users 1 not found.
Date Deposited: 14 Nov 2017 08:03
Last Modified: 25 Feb 2018 08:20
URI: http://eprints.skums.ac.ir/id/eprint/6362

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