Study of -629C/A polymorphism of cholesteryl ester transfer protein gene in statin effects on plasma high density lipoprotein cholesterol level

Amini Najafabadi, H. and Farrokhi, E. and Gatreh Samani, K. and Amini, S.A. and Hashemzadeh Chaleshtori, M. and Moradi, M.T. (2010) Study of -629C/A polymorphism of cholesteryl ester transfer protein gene in statin effects on plasma high density lipoprotein cholesterol level. Journal of Shahrekord University Of Medical Sciences, 12 (2).

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Abstract

Background and aim: Cholesteryl ester transfer protein (CETP) plays in HDL metabolism and in reverse cholesterol transport (RCT) pivotal role pathway. CETP gene variants such as -629C/A that affect HDL cholesterol directly, modulates CETP gene transcriptional activity. This study was aimed to determine influence of -629C/A polymorphism of CETP in statin effects with regard to plasma HDL cholesterol levels. Methods: In this descriptive-analytical study, 196 adult patients with LDL-C more than 120mg/dL were divided into two groups base on lovastatin and atorvastatin using. Lipid profile was measured in all subjects before and after treatment and -629C/A polymorphism of CETP promoter was studied using polymerase chain reaction/restriction fragment length polymorphism method. Data were compared with paired t-test and ANOVA in SPSS software. Results: Cholesterol was decreased and HDL was increased in AA genotype more than other genotypes by lovastatin, but ApoA1 was increased in CC genotype. ApoA1 also was increased in CC genotype more than AA or AC genotypes by atorvastatin. Conclusion: In CC genotype, lovastatin and specially atorvastatin increased ApoA1 in HDL particles more than other genotypes. Therefore, treatment with lovastatin and atorvastatin is more effective in patients with CC genotype for raising HDL particles activity.

Item Type: Article
Uncontrolled Keywords: Atorvastatin, Cholesteryl ester transfer protein (CETP), -629C/A, Polymorphism, Lovastatin, HDL-C.
Subjects: QU Biochemistry
QU Biochemistry > Cell biology and genetics
Divisions: Faculty of Medicine > Basic Sciences Academic Groups > Department of Biochemistry and Genetics
Reserach Vice-Chancellar Department > Cellular and Molecular Research Center
Reserach Vice-Chancellar Department > Clinical Biochemistry Research Center
Reserach Vice-Chancellar Department > Medical Plants Research Center
Depositing User: Users 1 not found.
Date Deposited: 14 Nov 2017 05:08
Last Modified: 14 Nov 2017 05:08
URI: http://eprints.skums.ac.ir/id/eprint/6352

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