Effect of Portulaca oleracea L vice versa silver sulfadiazine on burn wound healing in Balb/c mice

Rafiee-Vardanjani, Leila. and Sahinfard, Najmeh. and Rahimi-Madiseh, Mohammad and Ansari Samani, Roya. and Rahimi, Marzieh. and Parvin, Neda. and Taji-Eshkaftaki, Fatemeh. (2012) Effect of Portulaca oleracea L vice versa silver sulfadiazine on burn wound healing in Balb/c mice. Journal of Shahrekord University of Medical Sciences, 13 (6).

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Abstract

Background and aim: The effect of herbal medicine with antitoxidant activity on burn wound healing has been proven in various studies. Portulaca oleracea L (Purslane) is a rich source of antioxidants and fatty acids. This study was carried out to compare the effect of purslane and silver on the second-degree burn wound healing in Balb/c mice. Methods: In this preclinical study, burn wounds were made with a hot plate on the back of 85 Balb/c mice. Four groups of mice were treated topically for 21 days by vaseline, silver salfadiazin, 1% and 10% purslane. Wound size on days 0, 7, 14 and 21 were measured. Data were analyzed using Kruskal- Wallis and test. Results: Results showed that the recovery was observed in silver group, 10% purslane, 1% purslane and vaseline, respectively. There was no significant difference in burn wound healing between silver and 10% purslane groups on days 14 and 21 (P>0.05), but significant difference between vaseline and 10% purslane groups on days 14 and 21 (P<0.05). Conclusion: Regarding to the finding of this study, extracts of 10% purslane expedites the wound healing process in mice. Therefor, it might be beneficial in patients with burn wound.

Item Type: Article
Uncontrolled Keywords: Burn wound, Healing, purslane, Silver sulfadiazine
Subjects: QV pharmacology > QV 752 Pharmacognosy
Divisions: Reserach Vice-Chancellar Department > Medical Plants Research Center
Depositing User: zahra bagheri .
Date Deposited: 01 Nov 2017 07:44
Last Modified: 29 Jan 2018 08:46
URI: http://eprints.skums.ac.ir/id/eprint/6200

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