Effect of adding the herb Achillea millefolium on mouthwash on chemotherapy induced oral mucositis in cancer patients: A double-blind randomized controlled trial

Miranzadeh, Sedigheh. and Adib-Hajbaghery, Mohsen. and Soleymanpoor, Leila. and Ehsani, Majid. (2015) Effect of adding the herb Achillea millefolium on mouthwash on chemotherapy induced oral mucositis in cancer patients: A double-blind randomized controlled trial. European Journal of Oncology Nursing, 19.

[img]
Preview
Text
2000.pdf

Download (440kB) | Preview

Abstract

Background: Oral mucositis (OM) is a debilitating side-effect of chemotherapy. It has different complications, including impairment of drinking, eating and even talking, sometimes so severe that physician stops the therapy. Objective: Investigating the effect of Achillea millefolium distillate solution in the treatment of chemotherapy-induced OM. Interventions/methods: In this randomized controlled trial, 56 cancer patients with chemotherapyinduced OM were randomly assigned into control and experimental groups in similar blocks based on the severity of OM. The experimental group gargled 15 mL of a mixture of routine solution and distilled A. millefolium 4 times a day for 14 days while the control group gargled 15 mL of routine solution. The severity of OM was assessed at three times before, 7 and 14 days after intervention. Data was analyzed using Wilcoxon, KruskaleWallis, ManneWhitney U, Friedman, Chi-square and Fisher's exact tests. Results: The mean severity score of OM was 2.39 ± 0.875 in both groups at start of the study that was changed to 1.07 ± 0.85 and 0.32 ± 0.54 in the intervention group in days 7 and 14 (p < 0.001). However, the severity of OM was increased to 2.75 ± 0.87 and 2.89 ± 0.956 in the control group respectively (p < 0.001). Conclusions: A. millefolium distillate healed OM much more than the routine solution. Therefore, it is suggested to be used in patients with chemotherapy-induced OM. The study was registered in the Iranian Registry of Clinical Trials, Number: IRCT2013092214729N1

Item Type: Article
Uncontrolled Keywords: Achillea millefolium,Chemotherapy,Oral mucositis,Cancer,Mouthwashe
Subjects: QZ pathology-Neoplasms
QV pharmacology > QV 752 Pharmacognosy
Depositing User: Users 1 not found.
Date Deposited: 28 Oct 2017 04:18
Last Modified: 28 May 2018 04:35
URI: http://eprints.skums.ac.ir/id/eprint/6104

Actions (login required)

View Item View Item