characteristic Findings of primary sclerosing cholangitis on endoscopic Retrograde cholangiography: Which is the Most common Finding?

Mohammad Alizadeh, Amir houshang. and Shahnazi, Anahita. and rasoulzadeh, Aida. and Shams, esmaeel. and Mohammadi, Manijeh. and Darabi, Farideh. and Behdad, Mahnaz. (2012) characteristic Findings of primary sclerosing cholangitis on endoscopic Retrograde cholangiography: Which is the Most common Finding? Clinical medicine insights. Gastroenterology, 5 (1).

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Abstract

Abstract Background: Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease and one of the most common indications for cholangiography (ERCP). We undertook this study to clarify whether there is a specific pattern of involvement of the biliary tract in patients with PSC and to evaluate features of PSC disease on ERCP in order to be able to manage this disease better. Methods: This retrospective study included 45 patients admitted to Taleghani Hospital in 2004–2010 and diagnosed to have PSC on the basis of typical cholangiographic findings in combination with clinical and laboratory data. Patients suspected to have secondary sclerosing cholangitis were excluded. Demographic and clinical data were recorded, along with cholangiographic findings and the frequency of large duct and small duct PSC. Results: Forty-five patients of mean age 34.8 (range 15–66) years were included. Twenty-nine patients (64.4%) had inflammatory bowel disease, and the frequency of large duct PSC and small duct PSC was 93.4% and 6.6%, respectively. The intrahepatic ducts alone were involved in 11 (24.4%) patients and the extrahepatic ducts were involved in 14 (31.1%), with 17 (37.7%) patients having both intrahepatic and extrahepatic PSC. Three (6.6%) patients did not have bile duct involvement on ERCP, and their disease was diagnosed by liver biopsy as small duct PSC. The most common type of cholangiographic feature of intrahepatic duct involvement was type 2, found in 15 (33.3%) patients, with type 3 being the most common type of extrahepatic duct involvement and detected in 16 (35.5%) patients. Conclusion: Our study demonstrates that the most common PSC finding on ERCP is involvement of both the extrahepatic and intrahepatic bile ducts, with small duct PSC being less common than large duct PSC.

Item Type: Article
Uncontrolled Keywords: primary sclerosing cholangitis, small duct, large duct, endoscopic retrograde cholangiopancreatography
Subjects: WI Digestive System
Depositing User: zahra bagheri .
Date Deposited: 24 Oct 2017 10:16
Last Modified: 02 Jun 2018 04:08
URI: http://eprints.skums.ac.ir/id/eprint/6087

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