The effect of adding ferrous sulfate to methylphenidate on attention-deficit/hyperactivity disorder in children

Panahandeh, Gholamreza. and Vatani, Bahareh. and Safavi, Parvin. and Khoshdel, Abolfazl. (2017) The effect of adding ferrous sulfate to methylphenidate on attention-deficit/hyperactivity disorder in children. Journal of Advanced Pharmaceutical Technology & Research, 8 (4).


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Attention deficit/hyperactivity disorder (ADHD) is one of the most common psychiatric disorders in children with several complications. This study was conducted to investigate the effect of adding ferrous sulfate to methylphenidate in decreasing ADHD symptoms. This study was a double‑blind, randomized clinical trial. In this study, 42 nonanemic children with ADHD and serum ferritin below 30 mg/ml were enrolled according to convenience sampling and randomly assigned to two groups of 21 each, cases and controls. The two groups were matched for age and sex. The case group was administered with ferrous sulfate 5 mg/kg in addition to methylphenidate up to 1 mg/kg and the control group with methylphenidate alone. The scores on child symptoms inventory‑4 (CSI‑4) were recorded at baseline and after 2 months of treatment. Data were analyzed by t‑test, Pearson’s correlation coefficient, and repeated measures ANOVA in SPSS 16. The scores on CSI‑4 decreased significantly at month 2 in both groups (P < 0.001). The scores on attention deficit and hyperactivity subscales of the CSI‑4 were significantly lower in the case group than the control group (P < 0.05). The total score on CSI‑4 decreased more markedly in the case group (P < 0.04). Use of ferrous sulfate plus methylphenidate can be effective in reducing ADHD symptoms in nonanemic children with low serum ferritin.

Item Type: Article
Uncontrolled Keywords: Key words: Attention‑deficit/hyperactivity disorder, ferrous sulfate, methylphenidate
Subjects: WM Psychiatry
QU Biochemistry > Nutrition.vitamins
Divisions: Faculty of Medicine > Department of Clinical Sciences > Department of Psychiatry
Depositing User: zahra bagheri .
Date Deposited: 17 Oct 2017 06:48
Last Modified: 07 Apr 2018 05:17

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