A randomized, double-blind, controlled trial of testosterone gel treatment versus vehicle control on the facial hair of young men with beta-thalassemia major.

Mahdavi, Mohammad Reza. and Adabi, Morteza. and Fekri, Kiavash. and Kosaryan, Mehrnoush. and Saeedi, Majid. (2017) A randomized, double-blind, controlled trial of testosterone gel treatment versus vehicle control on the facial hair of young men with beta-thalassemia major. Journal of Dermatological Treatment, 18 (5).

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Abstract

OBJECTIVES: To determine whether the medical prescription of testosterone gel can successfully increase facial hairs in young men with beta-thalassemia major. METHODS: Thirty-two men with beta-thalassemia major, at least 15 years old (tanner stage 4), were randomized in four blocks according to age and serum testosterone level. The cases received 2.5% testosterone gel. The changes in the number of terminal hairs were evaluated by a dermatologist after 6 months. Student's t-test and paired t-test were used to compare the results. RESULTS: The serum testosterone levels of controls and cases were 9.5+/-5.7 (mean+/-SD) and 10.5+/-9.6 ng/l, respectively. The number of terminal hairs (per cm2) in cases (29.8+/-13.6) was significantly higher than that for controls (13.9+/-13.2) (p<0.005). One patient from each group complained of a sense of irritation. CONCLUSION: The 2.5% testosterone gel was effective and well tolerated in inducing the transformation of the terminal hairs of the beard area of thalassemic males.

Item Type: Article
Subjects: WH Hemic and Lymphatic System
WJ Urogenital System
WK Endocrine System
Divisions: Faculty of Medicine
Depositing User: Users 1 not found.
Date Deposited: 15 Oct 2017 08:09
Last Modified: 11 Jun 2018 06:56
URI: http://eprints.skums.ac.ir/id/eprint/5909

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