Immunogenicity and efficacy of the Hoshino strain of mumps (MMR Vaccine) in Iran

Mirzadeh, Farnoush. and Kheiri, S. and Hafziz, M. and Moghni, M. and Avijgan, Majid. (2011) Immunogenicity and efficacy of the Hoshino strain of mumps (MMR Vaccine) in Iran. East Afr J Public Health., 8 (2).

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Abstract

Background: Mumps is an infectious and common disease during childhood. The vaccination against some epidemic diseases like mumps has been introduced in national program. This report describes the immunogenicity and efficacy of Hoshino strain of mumps (included in MMR vaccine) in Iran during 2 years. Methods: Three hundred and thirty eight children aged 3-18 years from Shahr-e-Kord, Iran were enrolled. They were tested for mumps IgG using enzyme-linked immunosorbent assay (ELISA). The percent of susceptible mumps IgG negative children was 19.8% (67 subjects), among them, 36 received the MMR vaccination and successfully completed the study. Blood sample was collected by venipuncture at 3, 12, and 24 months after vaccination and serum samples were tested by ELISA for detection of mumps IgM and IgG. Results: The seroconversion rate was 86.1%, 77.7% and 75% at 3, 12, and 24 months after vaccination respectively. Conclusion: Although the early serocoversion rate was high, but later it declined to a level of 75% which is the same immunity as natural infection which means that the immunity after vaccination would not last for long period of time and there may be a need for introduction of the booster dose of vacci

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