Evaluation of effective parameters for the synthesis of poly (propylene fumarate) by Response Surface Methodology

Mir Mohammad Sadeghi, Gity. and Moztarzadeh, Fatollah. and Jafari, Yaser. and Shahbazi, Sara. (2014) Evaluation of effective parameters for the synthesis of poly (propylene fumarate) by Response Surface Methodology. Journal of Applied Polymer Science, 121 (20).

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Abstract

ABSTRACT: Poly(propylene fumarate) (PPF) is an unsaturated linear polyester, which was synthesized for potential applications in filling skeletal defects. The synthesis was carried out according to a two-step polymerization reaction. In this research, a functional relationship among three reaction factors [temperature, reaction time, and stoichiometry of the monomers] in the PPF synthesis was established by responses of the surface methodology/central composite design (CCD). After that, on the basis of the responses of CCD [increasing intensity ratio of the CAH/OAH peaks in Fourier transform infrared (FTIR) spectra], designed substances were synthesized and analyzed by FTIR spectroscopy. The synthesized PPF, based on the optimized synthesis conditions from CCD, had a high molecular weight, low hydroxyl group content, and optimum viscosity. According to the CCD response, the best product was obtained through with a molar ratio of diethyl fumarate/propylene glycol/ZnCl2/hydroquinone of 1:3.5:0.01:0.002 and a 17-h reaction time at 140C. Eventually, the synthesized PPF was characterized by FTIR spectroscopy, NMR, and gel permeation chromatography analyses.

Item Type: Article
Uncontrolled Keywords: KEYWORDS: biomedical applications; molding; polycondensation; synthesis and processing
Subjects: WA Public Health > Public Health Education WA.18 > WA 30 Social, Economic, and Environmental factor in public health
WA Public Health > WA 30 Social, Economic, and Environmental factor in public health

WE Musculoskeletal system
Depositing User: zahra bagheri .
Date Deposited: 14 Oct 2017 08:05
Last Modified: 11 Jun 2018 04:39
URI: http://eprints.skums.ac.ir/id/eprint/5870

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