Fatehi, D. and Ahadi, R. and Daneshi, A. and Dayani, M.A. (2017) IAGNOSTIC VALUE OF MAGNETIC RESONANCE SPECTROSCOPY IN MORPHOMETRICAL ANALYSIS OF BASAL GANGLIA IN PATIENTS WITH IDIOPATHIC GENERALIZED EPILEPSY. International journal of Applied Pharmaceutical and Biological Research,, 2 (3).
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Abstract
Idiopathic generalized epilepsy (IGE) is a kind of epilepsy that has tonic-colonic characteristic and myocolonic tensions and its clinical symptom starts from the first 20 years of the life. Proton magnetic resonance spectroscopy (H1-MRS) technique applies as a noninvasive procedure to find metabolic disorders by evaluating brain metabolites. Purpose of this study was to determine efficacy of the MRS in thalamus imaging of patients with IGE. Applying H1-MRS (technique: PRESS-CSI], we evaluated thalamus images of 63 people (35 controls: 23 males, 12 females, ranging in age 19-46 years, average: 34.8±0.62 years) and 28 IGE patients (10 males, 18 females, ranging in age 20-49 years, average: 37.4±1.04 years). The data analyzed by SPSS (v.20]. Comparing the average NAA/Cr for the right thalamus, a significant reduction was seen between the control group and the IGE patients (p<0.0001]. Likewise, for the left thalamus, the NAA/Cr was significantly decreased when we compared it for the control group and the IGE patients (p<0.001). H1-MRS could be a suitable diagnostic technique to evaluate epilepsy in IGE patients. The possible alteration of neuronal pathways in the thalamo-cortical circuit seems to play a critical role in epileptogenesis of IGE.
Item Type: | Article |
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Uncontrolled Keywords: | Keywords: Idiopathic epilepsy, thalamus, magnetic resonance spectroscopy |
Subjects: | WL Nervous system WN Radiology . Diagnostic Imaging QU Biochemistry > Cell biology and genetics |
Divisions: | Faculty of Medicine > Department of Clinical Sciences > Department of Radiology |
Depositing User: | Users 1 not found. |
Date Deposited: | 11 Oct 2017 05:04 |
Last Modified: | 11 Oct 2017 05:04 |
URI: | http://eprints.skums.ac.ir/id/eprint/5821 |
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