The association of miR-27a (rs895819) polymorphism with the risk of type 2 diabetes

Sari, Soyar. and Badr, Ramak. (2017) The association of miR-27a (rs895819) polymorphism with the risk of type 2 diabetes. Journal of Shahrekord Uuniversity of Medical Sciences, 19 (3).

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Abstract

Background and aims: Type 2 diabetes is an endocrine desease and one of the most common metabolic diseases in the world, and some environmental factors and genetic background are involved in the disease. Genetically, a large number of gene polymorphisms have been identified to be associated with this disease, but few studies have been conducted in polymorphisms miRNA and their correlation with type 2 diabetes. Among miRNAs, miR-27a involves in the predisposition to type 2 diabetes, and mutations can alter the miR-27a function and cause diabetes. The aim of the present study was to investigate the association of miR-27a (rs895819) with the risk of type 2 diabetes. Methods: In the present case-control study, 100 type 2 diabetes patients and 100 healthy individuals were randomly selected. Polymorphism miR-27a (rs895819) was investigated using PCR-RFLP method. To determine the balance or imbalance in two groups and the relationship between polymorphisms and the incidence of type 2 diabetes, Chi-square test was applied. Results: Significant differences in the genotype distribution of miR-27a (rs895819) in patients with type 2 diabetes in comparison to the healthy subjects indicated a P value equal to 0.038 (odds ratio: 2.63, 95% CI: 1.07-6.05). Conclusion: The results suggested that there is an association between miR-27a genetic variants and the incidence of type 2 diabetes. However, further studies are needed to evaluate the significance of genetic variants in different populations.

Item Type: Article
Uncontrolled Keywords: miR-27a, Polymorphism, Diabetes and DraIII restriction enzymes.
Subjects: WD Nutrition Disease and metabolic diseases
QU Biochemistry > Cell biology and genetics
Divisions: Reserach Vice-Chancellar Department > Journal of Shahrekord University of Medical Sciences
Depositing User: Users 1 not found.
Date Deposited: 14 Oct 2017 04:39
Last Modified: 03 Jun 2018 05:04
URI: http://eprints.skums.ac.ir/id/eprint/5809

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