Effect of naloxone on seizure duration after electroshock therapy (ECT

Abedinzadeh, Mohammadreza. and Hooshmand, Fariba. and nejafi, Mostafa. and Solati Dehkordi, Seyed kamal. (2004) Effect of naloxone on seizure duration after electroshock therapy (ECT. journal of shahrekord university of medical sciences, 5 (4).

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Abstract

ECT is a process in which a generalized seizure is induced by passing electrical current for 25 to 150 seconds through the brain under general anesthesia. It is a highly effective treatment for major depression, mania and schizophrenia. Seizure is terminated by active inhibitory processes. The inhibition of seizure is due to the production of endogenous opioids. Naloxone, as an opioid antagonist, may lessen the effect of endogenous opioids. This clinical trial study was conducted to determine the effect of naloxone on length of the seizure. Sixty patients (30 male and 30 female), who met the diagnostic criteria were included in this study. The control group comprised of 30 patients, received ECT without naloxone, and the experimental group comprised of 30 patients, received ECT and 2 mg naloxone (i.v.). Duration of seizure was compared between two groups by t-test. The mean of seizure length was 21.3s in the control and 27.8s in the experimental group. Therefore naloxone can be used for lengthening of seizure and consequently for improving its treatment benefit.

Item Type: Article
Uncontrolled Keywords: ECT, Naloxone, Opioid, Seizure
Subjects: QT physiology
WM Psychiatry
Divisions: Faculty of Medicine > Basic Sciences Academic Groups > Department of Physiology
Faculty of Medicine > Department of Clinical Sciences > Department of Anesthesiology
Faculty of Medicine > Department of Clinical Sciences > Department of Psychiatry
Reserach Vice-Chancellar Department > Journal of Shahrekord University of Medical Sciences
Depositing User: zahra bagheri .
Date Deposited: 27 Sep 2017 06:44
Last Modified: 28 May 2018 06:30
URI: http://eprints.skums.ac.ir/id/eprint/5709

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