Anti-inflammatory and analgesic effects of Coriandrum sativum L. in animal models

haj hashemi, Valiollah. and ghanadi, Alireza. and sharif, Badieh. (2003) Anti-inflammatory and analgesic effects of Coriandrum sativum L. in animal models. journal of shahrekord university of medical sciences, 5 (2).

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Abstract

An important part of ethnopharmacology is study of pharmacological effects of medicinal plants and natural compounds in animal models. In this study the anti-inflammatory and analgesic effects of Coriandrum sativum L. seeds were evaluated. The total hydroalcoholic and flavonoid extract of the seeds were prepared and concentrated. Essential oil of coriander was obtained by soxhlet extractor, using pentane as solvent. Carrageenan (CAR) test was used for evaluation of anti-inflammatory effect. In this test 100ml of CAR suspension (1%w/v) was injected into subplantar space of rat hind paw and volume of paw was measured at 0 and 3 hrs after injection. For evaluation of analgesic effect writhing and formalin tests were used. For Writhing test, acetic acid (1%v/v) at a dose of 10 ml/kg was injected intraperitonealy (i.p.) and 10 min later the number of writhes was counted during a 10 minutes period. In formalin test, the paw licking time was measured during phase 1(0-5 min) and phase 2 (20-25min) after injection of 50 ml of formalin (2.5%v/v). Gas chromatography (GC) and gas chromatography/mass spectrometry (GC/MS) analysis showed that linalool (83.1%) is the major constituent of coriander essential oil. Our results showed that Coriander had no anti-inflammatory effect in CAR test. In writhing test, only the essential oil (4ml/100g,P.O) had a significant effect (P<0.01). Total extract, polyphenolic extract and essential oil of coriander, had significant effect in both phases of formalin test. Since the major constituent of coriander essential oil is linalool, it seems that it may be responsible for the effects.

Item Type: Article
Uncontrolled Keywords: Coriander, Anti-inflammatory, Analgesic, Carrageenan, Writhing, Formalin, Linalool.
Subjects: QV pharmacology > QV 752 Pharmacognosy
Divisions: Reserach Vice-Chancellar Department > Journal of Shahrekord University of Medical Sciences
Depositing User: Users 1 not found.
Date Deposited: 26 Sep 2017 09:06
Last Modified: 19 May 2018 08:15
URI: http://eprints.skums.ac.ir/id/eprint/5702

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