Effects of aspirin on teratogenic characteristic of alcohol in limb morphoyenesis of mouse embryo

rafighdoost, Hooshang. and akbari, Mohammad. and heidari, zahra. (2003) Effects of aspirin on teratogenic characteristic of alcohol in limb morphoyenesis of mouse embryo. journal of shahrekord university of medical sciences, 5 (1).

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Abstract

Abnormalities caused by alcohol are very extensive and are called fetal alcoholic syndrome (FAS). There are some hypotheses about pathological mechanisms of alcohol. Based on one of the recent hypotheses, alcohol consumption can change maternal and fetal prostaglandin levels. On the other hand aspirin is a strong prostaglandin inhibitor and there are reports showing that simultaneous administration of alcohol and aspirin decreased the limbs and kidney abnormalities in mice offsprings. Others showed that aspirin had no inhibition on alcohol adverse effects. The aim of this study was to determine the effects of aspirin on teratogenic characteristic of alcohol in limb morphogenesis of mouse embryo 135 male and female mice (1 male for 3 females) were randomly divided into 5 groups. After vaginal plaque observation on the 8th day of gestation, controls received nothing while other groups received physiological serum, alcohol, aspirin and a combination of alcohol and aspirin respectively by intraperitoneal injection. On the 18th day of gestation animals were killed by cervical dislocation and embryos were observed for anomalies of the upper and lower limbs. Our results showed that limbs had lower height and weight and more anomalies in alcohol and aspirin group compared to the alcohol alone group. Thus administration of aspirin with alcohol does not decrease the rate of limb abnormalities and factors other than prostaglandin might involve in limb abnormalities.

Item Type: Article
Uncontrolled Keywords: Alcohol, Prostaglandin, Congenital abnormalities, Aspirin Teratogen.
Subjects: QS Human Anatomy
QS Human Anatomy

QU Biochemistry
Divisions: Reserach Vice-Chancellar Department > Journal of Shahrekord University of Medical Sciences
Depositing User: Users 1 not found.
Date Deposited: 26 Sep 2017 08:47
Last Modified: 30 Jan 2018 05:03
URI: http://eprints.skums.ac.ir/id/eprint/5699

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