Khosravian, Pegah. and Shafiee Ardestani, Mehdi. and Khoobi, Mehdi. and Ostad, Seyed Naser. and Abedin Dorkoosh, Farid. and Akbari Javar, Hamid. and Amanlou, Massoud. (2016) Mesoporous silica nanoparticles functionalized with folic acid/methionine for active targeted delivery of docetaxel. OncoTargets and therapy, 9.
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Abstract
Abstract: Mesoporous silica nanoparticles (MSNs) are known as carriers with high loading capacity and large functionalizable surface area for target-directed delivery. In this study, a series of docetaxel-loaded folic acid- or methionine-functionalized mesoporous silica nanoparticles (DTX/MSN-FA or DTX/MSN-Met) with large pores and amine groups at inner pore surface properties were prepared. The results showed that the MSNs were successfully synthesized, having good pay load and pH-sensitive drug release kinetics. The cellular investigation on MCF-7 cells showed better performance of cytotoxicity and cell apoptosis and an increase in cellular uptake of targeted nanoparticles. In vivo fluorescent imaging on healthy BALB/c mice proved that bare MSN-NH2 are mostly accumulated in the liver but MSN-FA or MSN-Met are more concentrated in the kidney. Importantly, ex vivo fluorescent images of tumor-induced BALB/c mice organs revealed the ability of MSN-FA to reach the tumor tissues. In conclusion, DTX/MSNs exhibited a good anticancer activity and enhanced the possibility of targeted drug delivery for breast cancer.
Item Type: | Article |
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Uncontrolled Keywords: | Keywords: targeted delivery, mesoporous silica nanoparticle, folic acid, methionine, docetaxel |
Subjects: | QT physiology QZ pathology-Neoplasms |
Divisions: | Reserach Vice-Chancellar Department > Medical Plants Research Center |
Depositing User: | Users 1 not found. |
Date Deposited: | 24 Sep 2017 04:46 |
Last Modified: | 18 Feb 2018 05:04 |
URI: | http://eprints.skums.ac.ir/id/eprint/5630 |
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