Effects of β -hydroxy- β -methylbutyrate on kidney parameters and body composition in untrained males after 8 weeks combination resistance training

Faramarzi, M. and Ghasempour, H.R. and Banitalebi, E. and Ghafoorian, M. and Ghatre-Samani, K. (2012) Effects of β -hydroxy- β -methylbutyrate on kidney parameters and body composition in untrained males after 8 weeks combination resistance training. journal of shahrekord university of medical sciences, 13 (6).


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Background and aim: It has not been precisely studied for its harmless effects of β-hydroxy β-methylbutyrate (HMB) in human yet and just a few studies have been done on its effects of the indices on the health in animal. The purpose of this study was to examine the effects of 8 weeks resistance training and consumption HMB (β-hydroxy β-methylbutyrate) on kidney parameters and body composition of untrained males. Methods: In this clinical trial, 24 untrained male students were selected and randomly divided to two groups. Group one took placebo (control n=14) and group two received HMB (case, n=10). The subjects were trained for 8 weeks, 3 sessions every week. Blood and urine samples were taken fasting, one day before and 2 days after resistant training. Creatinine and urea were measured and glomerular filtration rate (GFR) was also calculated. The weight and body composition of the subjects were analyzed by the body composition analyzer and the strength of lower and upper limbs were measured by the seat press and squat, respectively. Dependent and independent student t-test were used for statistical analysis. Results: Supplemental group had significant increase in lean body mass (P=0.002) and significant decrease (P=0.006) in fat mass. In addition, HMB group had more increase in strength of one repetition maximum than control group. Furthermore, HMB supplementation caused significant decrease (P=0.036) in blood urea nitrogen in urine. HMB supplement had no effects on blood urea, blood creatinine, urine creatinine and GFR. Conclusion: Consumtion of HMB supplement causes an increase in the lean body mass and the strength of one maximum repetition and decrease in body fat of untrained subjects. In addition consumption of HMB for 8 weeks has no side effect on renal function tests.

Item Type: Article
Uncontrolled Keywords: Blood urea nitrogen, β –hydroxy β-methylbutyrate, Resistance training
Subjects: WJ Urogenital System
QU Biochemistry
Divisions: Faculty of Medicine > Basic Sciences Academic Groups > Department of Physiology
Reserach Vice-Chancellar Department > Clinical Biochemistry Research Center
Reserach Vice-Chancellar Department > Journal of Shahrekord University of Medical Sciences
Depositing User: Users 1 not found.
Date Deposited: 20 Sep 2017 05:36
Last Modified: 20 Sep 2017 05:36
URI: http://eprints.skums.ac.ir/id/eprint/5505

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