Association of interleukin-18 gene polymorphism-137 G/C with allergic rhinitis.

Abolhassani, Marziyeh. and Hashemzade Chaleshtori, Morteza. and Iziy, Elham. and Motovalibashi, Majid. and khazraei, Hamid reza. and Ramazi, Shahin. (2015) Association of interleukin-18 gene polymorphism-137 G/C with allergic rhinitis. Journal of Gorgan University of Medical Sciences, 17 (2).


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Background and Objective: The interleukin-18 (IL-18) gene on chromosome 11 has been suggested as a susceptibility factor for allergies. It is a member of the IL-1 family that was originally described as interferon (IFN-γ)–inducing factor. IL-18 might initiate Th2 responses with production of IgE via the stimulation of IL-4 and IL-13 synthesis in mast cells and in basophil and eosinophil recruitment, such as allergic inflammation. This study was done to assess the association of Interleukin-18 gene polymorphism -137G/C with allergic rhinitis. Methods: This case-control study was performed on 293 allergic rhinitis patients and 218 healthy control volunteers .The IL-18 polymorphism was analyzed by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) analysis. Results: The frequency of the GG, GC and CC genotypes were 64.2%, 32.1% and 3.7% in healthy controls and 60.1%, 35.5% and 4.4% in allergic rhinitis patients, respectively. This diference was not significant. Conclusion: This study suggests that IL-18 polymorphism gene -137G/C may not be participated as a risk factor in the pathogenesis of allergic rhinitis.

Item Type: Article
Uncontrolled Keywords: Keywords: Allergic rhinitis, Interleukin-18, Polymorphism
Subjects: QU Biochemistry > Cell biology and genetics
WV Otolaryngology
Divisions: Faculty of Medicine > Department of Clinical Sciences > Department of Otolaryngology
Depositing User: Users 1 not found.
Date Deposited: 20 Sep 2017 05:25
Last Modified: 27 Mar 2018 04:53

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