The effect of sodium valproate on acetic acid-induced colitis in rats

Najafi, Ali and Motaghi, Ehsan and Hosseini, Mohammad Javad and Ghasemi-Pirbaluti, Masoumeh (2017) The effect of sodium valproate on acetic acid-induced colitis in rats. INFLAMMOPHARMACOLOGY, 25 (1). pp. 137-145.

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Abstract

Ulcerative colitis is a chronic recurrent disease with incomplete treatment options. The current article evaluated the effect of sodium valproate on acetic acid-induced ulcerative colitis in rats. Rats were randomly distributed into six groups including Sham group, colitis control group, sodium valproate treatment groups (50, 100 and 300 mg/kg, i.p.) and dexamethasone-treatment group. Dexamethasone was used as a reference drug. Colitis was induced by intracolonic instillation of 2 mL of 3% acetic acid solution. The efficacy of sodium valproate was evaluated by macroscopical and histopathological scoring systems, hematocrit measurement as well as biochemical analysis including myeloperoxidase (MPO) and pro-inflammatory cytokines assessment. Sodium valproate, particularly with doses of 100 and 300 mg/kg significantly improved weight loss, and macroscopic damage, reduced ulcer area, colon weight, microscopic colitis index and elevated hematocrit level. Biochemical experiments showed elevated levels of colonic MPO activity, interleukin 1 beta (IL-1 beta), interleukin 6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) in colitis control group. Treatment with sodium valproate at the doses of 100 and 300 mg/Kg) decreased the MPO activity and colonic concentrations of IL-1 beta, IL-6 and TNF-alpha. The results provide evidence that sodium valproate has a protective effect in acetic acid-induced ulcerative colitis which might be due to its anti-inflammatory activities, and it may be useful in patients with ulcerative colitis.

Item Type: Article
Uncontrolled Keywords: Sodium valproate; Ulcerative colitis; Rats; Interleukin 1 beta; Interleukin 6; Tumor necrosis factor-alpha
Subjects: WI Digestive System
QU Biochemistry
Divisions: Faculty of Medicine > Basic Sciences Academic Groups > Department of Immunology
Depositing User: zahra bagheri .
Date Deposited: 28 Jun 2017 08:22
Last Modified: 03 Jul 2017 09:49
URI: http://eprints.skums.ac.ir/id/eprint/550

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