Cytotoxic Evaluation of Some Fused Pyridazino- and Pyrrolo-quinazolinones Derivatives on Melanoma and Prostate Cell Lines.

Vaseghi, Golnaz. and Jafari-Dehkordi, Elham. and Hassanzadeh, Farshid. and Haghjooy-Javanmard, Shaghayegh. and Dana, Nasim. and Rafieian-Kopaei, Mahmoud. (2017) Cytotoxic Evaluation of Some Fused Pyridazino- and Pyrrolo-quinazolinones Derivatives on Melanoma and Prostate Cell Lines. Advanced biomedical research, 6. p. 76. ISSN 2277-9175

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Abstract

BACKGROUND Quinazolinon as an important class of heterocycles is attractive in medicinal research areas due to their wide range of biological effects. Cytotoxic activities of the quinazolinone derivatives in various cell lines including: HeLa, L1210 (mouse lymphocytic leukemia) and HT29 (human colon adenocarcinoma) were reported. MATERIALS AND METHODS In this study, a number of newly made tricycles quinazolinone derivatives such as fused pyridazino-quinazolinones and fused pyrrolo-quinazolinones were evaluated on two cancerous cell lines, melanoma (B16F10) and prostate (PC3) using the 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium bromide colorimetric assay. RESULTS The results of cytotoxicity evaluations indicated that almost all of the compounds at the concentrations of 10 and 100 μM showed significant differences in viability in comparison with negative control at 48 h exposure (P < 0.05). However, during 24 h exposure some of the compounds showed cytotoxicity activity. CONCLUSION Results showed that both cell lines were sensitive to synthesized compounds and longer duration of exposure (48 h) had better results compared to that of 24 h screening.

Item Type: Article
Uncontrolled Keywords: Keywords: Cytotoxic, melanoma and prostate cancer, quinazolinone
Subjects: WJ Urogenital System
QZ pathology-Neoplasms
QV pharmacology > QV 600 Toxicology
Divisions: Reserach Vice-Chancellar Department > Medical Plants Research Center
Depositing User: zahra bagheri .
Date Deposited: 20 Sep 2017 04:07
Last Modified: 03 Mar 2018 07:03
URI: http://eprints.skums.ac.ir/id/eprint/5389

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