Effect of insecticide poisoning of methoxychlor on the production of gonadotropin hormones in adult male rats

Rezaei-Zarchi, Saeid. and Alikhani-Mehrjerdi, Hekmat. and Zand, Ali Mohammad. and Olad, GholamReza. and Hamidi, Bahram. and Imani, Saber. (2013) Effect of insecticide poisoning of methoxychlor on the production of gonadotropin hormones in adult male rats. journal of shahrekord university of medical sciences, 14 (6).


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Background and aims: Methoxychlor pesticide is widely used to replace DDT. In this study, the possible effect of Methoxychlor was investigated on the hormone level of LH, FSH, testosterone, spermatogenesis and its possible role in male infertility. Methods: In this experimental study, 48 Wistar male rats were studied in six groups of 8. Different concentrations of the substance were injected in the experimental groups, i.e. 5, 50, 100, 500 and 1000 grams per liter per day. After 15 days, blood samples were taken and the levels of the hormone were checked. Normal distribution and statistical evaluation of data respectively was performed using ANOVA one-way analysis of variance and Paired t-test. P less than 0.05 were considered as statistically significant. Results: Results showed a significant decrease in the amount of FSH and testosterone concentrations in the experimental group injected 100, 500 and 1000 grams per liter Methoxychlor, but LH levels in groups of 500 and 1000 grams per liter Methoxychlor showed a significant decrease. Due to chlorine in the group 1000 mg per liter. The density of sperm cells in the center of the spermatogenesis tube in the experimental group which received 1000mg/lit methoxychlor decreased compared to the control group.s Conclusion: Methoxychlor causes male sexual imbalances by changing in LH, FSH hormones concentrations, sperm condense, body and tastes weight

Item Type: Article
Uncontrolled Keywords: Methoxychlor, DDT, LH, FSH, Testosterone, Spermatogenes
Subjects: WA Public Health
Divisions: Reserach Vice-Chancellar Department > Journal of Shahrekord University of Medical Sciences
Depositing User: zahra bagheri .
Date Deposited: 19 Sep 2017 03:52
Last Modified: 07 Mar 2018 09:25
URI: http://eprints.skums.ac.ir/id/eprint/5328

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