Molecular imaging using by diffusion-weighted imaging of brain tumor through signal intensity: Progress in molecular cancer imaging

Mirfendereski, S. and Shabani, A. and Rostamzadeh, A. and Fatehi, D. (2017) Molecular imaging using by diffusion-weighted imaging of brain tumor through signal intensity: Progress in molecular cancer imaging. Research Journal of Pharmacy and Technology, 10 (6). pp. 1767-1771.

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Abstract

Introduction: Characterizing the variations of the brain tumors has the significant effect in the treatment process of affected patients. Brain metastatic tumors are usually diagnosed following by the neurological symptoms in patients. The purpose of this thesis is the role of diffusion-weighted-magnetic resonance imaging (DW-MRI) and apparent diffusion coefficient (ADC) values in the evaluation of different benign and malignant brain mass lesions before surgery with histopathological correlation. Materials and Methods: In this study MR examination of 54 patients who with brain metastatic tumor referring to 7th-Tir Hospital were randomly selected and imaged with T2W Multi-echo sequences and GRE-EPI (DWI) in addition to taking the routine sequence of the brain. Results: In analyzing the data for ADCmin values were measured within the tumors and mean values were evaluated regarding statistical differences between groups.9 The ADCmin values of low-grade gliomas(1.09 ± 0.20 × 10−3 mm2/s) were signi=icantly higher (p < .001) than those of other tumors. Generally, ADC value of 0.5613 ± 0.02580 indicates brain metastatic tumors with lung origin, ADC value of 1.009 ± 0.03820 tumors with liver and breast origin, and ADC value of 1.556 ± 0.03500 tumors with colon and prostate origin. Conclusion: According to our results, Diffusion parameters during treatment were evaluated for early noninvasive biomarkers. The ADC changes from mid- to post-treatment suggest such a possible early non-invasive biomarker.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: Keywords: Molecular Imaging, Apparent diffusion coefficient, Diffusion weighted imaging, Brain tumor.
Subjects: WL Nervous system
WN Radiology . Diagnostic Imaging
Divisions: Faculty of Medicine > Basic Sciences Academic Groups > Department of Anatomy (Histology and Embryology
Faculty of Medicine > Basic Sciences Academic Groups > Department of Medical Physics
Faculty of Medicine > Department of Clinical Sciences > Department of Radiology
Depositing User: zahra bagheri .
Date Deposited: 19 Sep 2017 04:30
Last Modified: 19 Sep 2017 04:30
URI: http://eprints.skums.ac.ir/id/eprint/5297

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