Comparison of vaginal ointment of honey and clotrimazole for treatment of vulvovaginal candidiasis: A random clinical trial

Banaeian-Borujeni, Shayesteh and Sereshti, Manijeh. and Rafieian, Morteza. and Farahbod, Farinaz. and Kheiri, Soleiman. (2017) Comparison of vaginal ointment of honey and clotrimazole for treatment of vulvovaginal candidiasis: A random clinical trial. Journal de Mycologie Medicale.

Full text not available from this repository.
Official URL:


BACKGROUND AND OBJECTIVE: Vulvovaginal candidiasis (VVC) is the most prevalent vaginitis in women, accounting for 10 million medical referrals a year. Vaginal clotrimazole is a drug of choice for VVC treatment. However, increased drug resistance to this microorganism has led to an interest in naturally derived antifungal drugs. This study was conducted to compare honey vaginal ointment and clotrimazole vaginal ointment for VVC treatment. METHODS: Eighty women diagnosed with VVC were assigned to two groups for honey ointment and clotrimazole ointment treatment using a simple randomization rule. The ointments were applied at night for seven days. The disease symptoms including inflammation, vaginal discharge, and irritation at baseline in the fourth and eighth days of treatment were examined and compared between the two groups. The data was analyzed by SPSS version 20 with the Friedman test, Chi-square test, and independent t-test. P<0.05 was considered as the significance. RESULTS: The two groups were similar for inflammation severity, irritation, and discharge at baseline. In both the groups, the symptoms disappeared after treatment. On the eighth day of treatment, there was a significant difference in inflammation and vaginal discharge between the two groups. Inflammation (P=0.002) and vaginal discharge (P=0.003) recovered better in the clotrimazole group. But there was no significant difference in irritation severity and satisfaction with treatment between the two groups. In the two groups, no side effects were reported. CONCLUSION: Honey contributes to treating VVC. Thanks to the popular positive attitudes of honey, its availability, no need for sterility, and its cost-effectiveness, it is a choice of treatment for VVC. Copyright © 2017. Published by Elsevier Masson SAS.

Item Type: Article
Additional Information: cited By 0; Article in Press
Uncontrolled Keywords: Candida albicans; Clotrimazole; Honey; Vaginitis
Subjects: WJ Urogenital System
QV pharmacology > QV 752 Pharmacognosy
Divisions: Faculty of Medicine > Department of Clinical Sciences > Department of Obstetrics and Gynecology
Faculty of Nursing and Midwifery > Department of Midwifery
Reserach Vice-Chancellar Department > Clinical Biochemistry Research Center
Reserach Vice-Chancellar Department > Medical Plants Research Center
Depositing User: Users 1 not found.
Date Deposited: 19 Sep 2017 03:17
Last Modified: 30 May 2018 03:52

Actions (login required)

View Item View Item