Effect of ondansetron on prevention of ventilator associated pneumonia in intensive care unit patients in Kashani hospital in 2013

Madineh, Hossein. and Rahimi, Omolbanin. and Abedin Zadeh, Mohammad. and Kabiri, Majid. (2017) Effect of ondansetron on prevention of ventilator associated pneumonia in intensive care unit patients in Kashani hospital in 2013. Journal of Clinical and Diagnostic Research, 11 (8). UC05-UC08.

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Abstract

Abstract: Introduction: Ventilator Associated Pneumonia (VAP) is the second common infections with high mortality (24-40%). One way to prevent VAP is ondansetron injection. Ondansetron is a reliable and safe drug and it is currently used in the prevention of nausea and vomiting and has no side effects. Aim: To examine the effect of ondansetron on prevention of VAP in Intensive Care Unit () patients. Materials and Methods: This was a randomized clinical trial study (IRCT201406156480N6) carried out in Kashani hospital, Iran in 2013 on 80 patients aged between 15-65 years. They were randomly allocated to two equal groups (n=40). The first group injected 4 mg ondansetron twice daily for five days. The other group injected distilled water as placebo. The amount of VAP was examined in two groups. The collected data were analysed by SPSS software through Fisher-exact test. Results: Eleven patients (13.8%) were diagnosed with pneumonia. Among them, 9(81.8%) patients were male and two patients (18.2%) were female. The incidences of VAP in Case Group were 5 patients (12.5%) and in Control Group were 6 patients (15%) (p=0.74). Result showed that VAP in Case Group was lesser than that of in the Control Group, but this difference was not significant. Conclusion: Ondansetron had no effect on VAP; vomiting alone does not lead to VAP, instead silent aspiration cause it. None of factors such as age, sex, weight, smoking, drug addiction was shown to be effective in VAP. Instead, comorbidity was shown to be influential in VAP. Copyright of Journal of Clinical & Diagnostic Research is the property of JCDR Research & Publications Private Limited and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: Inflammation of the Lung, Nosocomial Infections, Pulmonary Diseases, Respiratory Tract Diseases
Subjects: WC Communicable Diseases > Infection.Bacterial Infections
WF Respiratory System
Divisions: Faculty of Medicine > Department of Clinical Sciences > Department of Anesthesiology
Depositing User: zahra bagheri .
Date Deposited: 18 Sep 2017 07:57
Last Modified: 06 Mar 2018 09:54
URI: http://eprints.skums.ac.ir/id/eprint/5164

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