Anticancer Activity and Phenolic Compounds of Pistacia atlantica Extract

Hashemi, L. and Asadi-Samani, M. and Moradi, M.T. and Alidadi, S. (2017) Anticancer Activity and Phenolic Compounds of Pistacia atlantica Extract. INTERNATIONAL JOURNAL OF PHARMACEUTICAL AND PHYTOPHARMACOLOGICAL RESEARCH, 7 (2). pp. 26-31.

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Abstract

Recently a lot of studies have been conducted to identify natural compounds for prevention of the development and recurrence of cancers. The present study aimed to determine phytochemical content and anti proliferative activity of Pistacia atlantica extract. Ethanolic extract of Pistacia atlantica was prepared. The antioxidant activity, total phenol, flavonoid and flavonol content of the extract were evaluated. Cytotoxicity activity of extract on AGS and HeLa cell lines was evaluated by MTT assay 48 hours after treatment. The antioxidant activity of extract was 4.6 +/- 0.66 mu g/ml while it was 25.41 +/- 1.89 mu g/ml for butylated hydroxytoluene (BHT). The total phenol, flavonoid and flavonol contents were 269 mg GAE/g, 40.7 mg RUT/g and 88.12 mg RUT/g, respectively. The extract inhibited the proliferation of AGS, HeLa and HDFs cells with IC50 values of 382.3 mu g/m, 332.3 mu g/ml and 896.3, respectively. This study revealed that the extract of Pistacia atlantica can suppress the proliferation of gastric carcinoma and cervical cancer cells. The plant with high phytoconstituents could be a promising source of anticancer drugs.

Item Type: Article
Uncontrolled Keywords: Pistacia atlantica; Cancer; Antioxidant; Proliferation
Subjects: QZ pathology-Neoplasms
QV pharmacology > QV 752 Pharmacognosy
Divisions: Reserach Vice-Chancellar Department > student research center
Depositing User: zahra bagheri .
Date Deposited: 28 Jun 2017 07:44
Last Modified: 03 Jul 2017 09:41
URI: http://eprints.skums.ac.ir/id/eprint/515

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