Serum miRNAs as Biomarkers for the Diagnosis and Prognosis of Thyroid Cancer: A Comprehensive Review of the Literature

Mahmoudian Sani, Mohammad Reza. and Mehri-Ghahfarrokhi, Ameneh. and Asadi-Samani, Majid. and Mobini, Gholam Reza. (2017) Serum miRNAs as Biomarkers for the Diagnosis and Prognosis of Thyroid Cancer: A Comprehensive Review of the Literature. EUROPEAN THYROID JOURNAL, 6 (4). pp. 171-177.

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Abstract

Background/Objectives: Thyroid cancer is the most common endocrine malignancy and accounts for 1% of cancers. In recent years, there has been much interest in the feasibility of using miRNAs or miRNA panels as biomarkers for the diagnosis of thyroid cancer. miRNAs are noncoding RNAs with 21-23 nucleotides that are highly conserved during evolution. They have been proposed as regulators of gene expression, apoptosis, cancer, and cell growth and differentiation. Methods: The Directory of Open Access Journals (DOAJ), Google Scholar, PubMed (NLM), LISTA (EBSCO), and Web of Science were searched. Results: The serum level of miRNAs (miRNA-375, 34a, 145b, 221, 222, 155, Let-7, 181b) can be used as molecular markers for the diagnosis and prognosis of thyroid cancer in the serum samples of patients with thyroid glands. Conclusions: Given that most common methods for the screening of thyroid cancer cannot detect the disease in its early stages, identifying miRNAs that are released in the bloodstream during the gradual progression of the disease is considered a key method in the early diagnosis of thyroid cancers. (C) 2017 European Thyroid Association Published by S. Karger AG, Basel

Item Type: Article
Uncontrolled Keywords: miRNA; Biomarker; Thyroid cancer; Fine-needle aspiration biopsy
Subjects: WK Endocrine System
QZ pathology-Neoplasms
Divisions: Reserach Vice-Chancellar Department > Cellular and Molecular Research Center
Reserach Vice-Chancellar Department > student research center
Depositing User: zahra bagheri .
Date Deposited: 18 Sep 2017 04:01
Last Modified: 11 Jun 2018 07:39
URI: http://eprints.skums.ac.ir/id/eprint/5093

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