The effect of theophylline on acetic acid induced ulcerative colitis in rats

Ghasemi-Pirbaluti, Masoumeh. and Motaghi, Ehsan and Najafi, Ali and Hosseini, Mohammad Javad. (2017) The effect of theophylline on acetic acid induced ulcerative colitis in rats. BIOMEDICINE & PHARMACOTHERAPY, 90. pp. 153-159.

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Abstract

Background: Ulcerative colitis is a relapsing inflammatory disorder of the colon. There is a need to explore the new treatments for this disorder. Theophylline, a competitive inhibitor of phosphodiesterase, is shown to have anti-inflammatory properties. However, the effect of theophylline on ulcerative colitis has not yet been investigated. The present study evaluated the effect of theophylline on acetic acid induced ulcerative colitis in rats. Materials and methods: Colitis was induced by instillation of 2 ml of acetic acid solution (3%). Colon samples were evaluated grossly and microscopically and assayed for myeloperoxidase (MPO) activity and proinflammatory cytokine concentrations. Results: Treatment with theophylline at the doses of 20 and 50 mg/kg attenuated acetic acid induced ulcerative colitis as shown by improvement in body weight loss, macroscopic score, ulcer area, hematocrit and histopathological score. Theophylline treatment also reduced MPO activity and tumor necrosis factor-alpha (TNF-alpha), interleukin 1 beta (IL-1 beta) and interleukin 6 (IL-6) concentrations in inflamed colon. Conclusion: Theophylline has a protective effect in acetic acid-induced ulcerative colitis which might be due to its anti-inflammatory activities. Therefore, theophylline has the potential to be used for successful treatment of ulcerative colitis. (C) 2017 Elsevier Masson SAS. All rights reserved.

Item Type: Article
Uncontrolled Keywords: Theophylline; Ulcerative colitis; Cytokine; Ulceration; Myeloperoxidase
Subjects: WI Digestive System
QV pharmacology > QV 704 Pharmaceutics
Divisions: Faculty of Health > Department of Epidemiology
Depositing User: zahra bagheri .
Date Deposited: 17 Sep 2017 07:47
Last Modified: 30 May 2018 05:42
URI: http://eprints.skums.ac.ir/id/eprint/5024

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