The effect of menthol on acute experimental colitis in rats

Ghasemi-Pirbaluti, M. and Motaghi, E. and Bozorgi, H. (2017) The effect of menthol on acute experimental colitis in rats. EUROPEAN JOURNAL OF PHARMACOLOGY, 805. pp. 101-107.

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Abstract

Menthol is an aromatic compound with high antiinflammatory activity. The purpose of the current research is to investigate the effectiveness of menthol on acetic acid induced acute colitis in rats. Animals were injected with menthol (20 and 50 and 80 mg/kg, i.p.) 24 h prior to induction of colitis for 3 consecutive days. Menthol at medium and higher doses similar to dexamethasone as a reference drug significantly reduced body weight loss, macroscopic damage score, ulcer area, colon weight, colon length and improved hematocrit in rats with colitis. The histopathological examination also confirmed anti-colitic effects of menthol. Menthol also reduced significantly the colonic levels of tumor necrosis factor-alpha (TNF-alpha), interleukin 1 beta (IL-1 beta), interleukin 6 (IL-6) and myeloperoxidase (MPO) activity in inflamed colons. Thus, the findings of the current study provide evidence that menthol may be beneficial in patients suffering from acute ulcerative colitis.

Item Type: Article
Uncontrolled Keywords: Ulcerative colitis; Menthol; Acute inflammation; Tumor necrosis factor alpha; Interleukin 1 beta; Interleukin 6
Subjects: WI Digestive System
QU Biochemistry
Divisions: Faculty of Medicine > Basic Sciences Academic Groups > Department of Immunology
Depositing User: zahra bagheri .
Date Deposited: 28 Jun 2017 05:52
Last Modified: 03 Jul 2017 09:40
URI: http://eprints.skums.ac.ir/id/eprint/485

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