Bioinformatics methods shows the probability of miR-142, miR-146 & miR-150’s role in differentiation of naïve cd4+ to Th17 cells in multiple sclerosis.

Hosseini, A. and Ghaedi, K. and teimuri, Sh. and Naghavian, R. and Nasr esfahani, M.H. Bioinformatics methods shows the probability of miR-142, miR-146 & miR-150’s role in differentiation of naïve cd4+ to Th17 cells in multiple sclerosis. journal of shahrekord university of medical sciences.

[img]
Preview
Text
109.pdf

Download (902kB) | Preview

Abstract

Background and aims: MiRNAs are a class of non-coding RNAs that take part in various cellular processes. Recently dysregulation of these small molecules reported in numerous disorders. Unfortunately prevalence of Multiple sclerosis (MS) as an autoimmune disease is rising nowadays in Iran. Th17 cells are the most important cell in this disease. In this study, we have predicted possible role of 3 miRNAs, miR142, miR-146a and miR-150 which could control Th17 differentiation. So, possibly it influences on MS onset and progress. Methods: Using miRwalk database as an integrative database which utilizes 10 different algorithms to predict miRNA-mRNA interaction, it was investigated probable interaction of miRNAs and genes that participate in Th17 differentiation. Results: Based on this study, 3 distinct miRNAs, miR-142, miR-146a and miR-150, were predicted to have a potential role in induction of Th17 differentiation. Therefore, control of these miRNAs could reduce MS symptoms. Conclusion: Conclusively, miR-142, miR-146a and miR-150 may be up-regulated in Th17 of MS patients, since bioinformatics data have shown that these miRNAs suppress negative regulator genes in Th17 differentiation. Thus, several therapeutic approaches may be considered for these miRNAs besides of their application as the valuable prognostic/diagnostic biomarkers in detection of various stages of MS.

Item Type: Article
Uncontrolled Keywords: Multiple sclerosis, miRNA, Th17 cells.
Subjects: WL Nervous system
QU Biochemistry
Divisions: Reserach Vice-Chancellar Department > Journal of Shahrekord University of Medical Sciences
Depositing User: zahra bagheri .
Date Deposited: 11 Sep 2017 08:43
Last Modified: 11 Sep 2017 08:43
URI: http://eprints.skums.ac.ir/id/eprint/4834

Actions (login required)

View Item View Item