Effect of Chaerophyllum macropodum extracts on Trichomonas vaginalis in vitro

Yousofi Darani, Hossein. and Sharafi, Seyedeh Maryam. and Jafari, Rasool. and Yousefi, Hossein Ali. and Jafari, Azizullah. and Ghanadian, Mostafa. and Asghari, Gholamreza. and Jabari, Maryam. (2015) Effect of Chaerophyllum macropodum extracts on Trichomonas vaginalis in vitro. Journal of HerbMed Pharmacology, 4 (2).

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Abstract

Introduction: Trichomonas vaginalis (T. vaginalis) is a protozoan parasite causing trichomoniasis or trichomonal vaginitis. The infection is considered as non-viral sexually transmitted disease (STD). Metronidazole and Tinidazole are now the drugs of choice for the treatment of this infection. However, resistant to these drugs has also been reported. So it is necessary to search for effective alternative drugs with fewer side effects. Chaerophyllum macropodum (C. macropodum) plant have been used against some parasites. Therefore, in this study the effects of different extracts of this plant on T. vaginalis in culture media have been investigated. Methods: In this experimental study hydro-ethanol extracts of C. macropodum leaves were prepared. Anti-T. vaginalis activities of the extracts were tested in concentrations of 2, 4, 8, 16, 32, 40, 50, 60, 80, 100 and 150 mg/ml following 24, 48 and 72 hours of incubation of cultured media. Results: All extract concentrations showed some degrees of growth inhibition activity on T. vaginalis. However crude extract was more efficient. Conclusion: C. macropodum showed an anti-T. vaginalis activity. More investigations are recommended to use this plant as an antiparasitic drug.

Item Type: Article
Uncontrolled Keywords: Trichomonas vaginalis Chaerophyllum macropodum Trichomoniasis Hydro-Alcoholic Extract
Subjects: WC Communicable Diseases
WJ Urogenital System
QV pharmacology > QV 752 Pharmacognosy
Divisions: Reserach Vice-Chancellar Department > Journal of Herbmed Pharmacology
Depositing User: zahra bagheri .
Date Deposited: 11 Sep 2017 08:05
Last Modified: 19 May 2018 07:01
URI: http://eprints.skums.ac.ir/id/eprint/4828

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